Seroatlas · Human Serome Atlas

FAM187A

Ig-like V-type domain-containing protein FAM187A

Also known as: F187A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFU0
Gene: FAM187A
Ensembl: ENSG00000214447
Chromosome: 17
Canonical length: 413 aa
Protein class: Predicted membrane proteins
Subcellular location: Acrosome

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

413 residues, UniProt reviewed canonical sequence.

>A6NFU0|FAM187A
     1  MHLALTTVLL WAWGLQAFEI VEKENIFQRT PCPAFLMFEN AAYLADMSFE LPCHCKPEEV
    61  PAVVWFYQKH LGSSHTKVLT DFDGRVLTEA AQVRVGSDML TRFSIRMFSL LVFRAQSEDS
   121  GLYFCGTRKG DYFYAYDVDI QNSEGMVATF QDKGQEPFAD EYYGHLHVFT TFWEWTPCDR
   181  CGVRGEQWRI GLCYLQSPDL SPRYLKAVPD VVSCGSRAVP RKLRTKARDH TPEVLVRSCL
   241  VPCEKTKTIR EGVLAIINYV SKVGSRPWVP QVPIQFHQQR LGHGLIISCP GARPEHAVAW
   301  DKDRQHLYRT QYLKGVNRSM RVFIDHGNQL HIRFTQLDDR GIYYCWRQGV LVAGFRLGVT
   361  SHGHYPASFS DPETRSAVEL TLIGYLLITA VFVTIHFCRC CCYLFHCCPS FSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM187A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 4.5 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 4.5 nTPM
retina: 2.5 nTPM
fallopian tube: 2.2 nTPM
testis: 1.2 nTPM
pituitary gland: 1 nTPM
thyroid gland: 1 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
b-cells: 0 nCPM

Immune cell

classical monocyte: 0.4 nTPM
total PBMC: 0.2 nTPM
eosinophil: 0.1 nTPM
myeloid DC: 0.1 nTPM
NK-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM

Brain region

midbrain: 5.4 nTPM
choroid plexus: 3.8 nTPM
hypothalamus: 3 nTPM
medulla oblongata: 3 nTPM
cerebral cortex: 2.6 nTPM
basal ganglia: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 1.43

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM187A as an antibody target. Whether an autoantibody or antibody against FAM187A could matter depends on whether native FAM187A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM187A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM187A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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