Seroatlas · Human Serome Atlas

FAM186A

Protein FAM186A

Also known as: F186A_HUMAN, LOC121006

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NE01
Gene: FAM186A
Ensembl: ENSG00000185958
Chromosome: 12
Canonical length: 2351 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

No narrative summary is available for FAM186A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

2351 residues, UniProt reviewed canonical sequence.

>A6NE01|FAM186A
     1  MFFKMKNEID NDPESEKCIK DSTIMRREPQ NILSPLMLPN LEIPFSVKDI ISRIERAQLH
    61  RAREDIDMQL SEIMNNVHRI MTRYTLVFNS SSERNVSLTE HKKKQRTNFL EKMATYAKTI
   121  EIREKTLANI LAWLEEWNDV LSEMTLMDVD EHHHWIAQME LLPDTLKAIE NNVKILSRFS
   181  TSFLDEKKKQ KKKILSRGTL WKSWKERVIK RPSTARALRP DQMISDQLAT NTKVSEIQGM
   241  LQELIGTTMF STLENNAIKY ISSTIVNLST ALSMLNDELK CVNFQSSTVY AHETSEAEKE
   301  LSLKIIRDLS NENEMLQQKL QDAEEKCEQL IRSKIVIEQL YAKLSTSSTL KVLPGPSPQS
   361  SRAIIKVGDT EDNMDNILDK ELENIVDEVQ RKETKDSGIK WDSTISYTAQ AERTPDLTEL
   421  RQQPVASEDI SEDSTKDNVS LKKGDFYQED ETDEYQSWKR SHKKATYVYE TSGPNLSDNK
   481  SGQKVSEAKP SQYYELQVLK KKRKEMKSFS EDKSKSPTEA KRKHLSLTET KSQGGKSGTS
   541  MMMLEQFRKV KRESPFDKRP TAAEIKVEPT TESLDKEGKG EIRSLVEPLS MIQFDDTAEP
   601  QKGKIKGKKH HISSGTITSK EEKTEEKEEL TKQVKSHQLV KSLSRVAKET SESTRVLESP
   661  DGKSEQSNLE EFQEAIMAFL KQKIDNIGKA FDKKTVPKEE ELLKRAEAEK LGIIKAKMEE
   721  YFQKVAETVT KILRKYKDTK KEEQVGEKPI KQKKVVSFMP GLHFQKSPIS AKSESSTLLS
   781  YESTDPVINN LIQMILAEIE SERDIPTVST VQKDHKEKEK QRQEQYLQEG QEQMSGMSLK
   841  QQLLGERNLL KEHYEKISEN WEEKKAWLQM KEGKQEQQSQ KQWQEEEMWK EEQKQATPKQ
   901  AEQEEKQKQR GQEEEELPKS SLQRLEEGTQ KMKTQGLLLE KENGQMRQIQ KEAKHLGPHR
   961  RREKGKEKQK PERGLEDLER QIKTKDQMQM KETQPKELEK MVIQTPMTLS PRWKSVLKDV
  1021  QRSYEGKEFQ RNLKTLENLP DEKEPISITP PPSLQYSLPG ALPISGQPLT KCIHLTPQQA
  1081  QEVGITLTPQ QAQAQGITLT LQQAQELGIP LTPQQAQALE ILFTPQQAQA LGIPLTPQQT
  1141  QVQGITLTPQ QDQAPGISLT TQQAQKLGIP LTPQQAQALG IPLTPQQAQE LGIPLTPQQA
  1201  QALRVSLTPQ QAQELGIPLT PQQAQALGIT LTLQQAQQLG IPLTPQQAQA LGITLTPKQV
  1261  QELGIPLTPQ QAQALGITLT PKQAQELGIP LNPQQAQTLG IPLTPKQAQA LGIPFTPQQA
  1321  QALGIPLTPQ QAQTQEITLT PQQAQALGMP LTTQQAQELG IPLTPQHAQA LGMPLTTQQA
  1381  QELGIPLTPQ QAQALGMPLT TQQAQELGIP LTPQQAQELG IPFTPQQAQA QEITLTPQQA
  1441  QALGMPLTAQ QAQELGITLT PQQAQELGIP LTPQQAQALG IPLIPPQAQE LGIPLTPQQA
  1501  QALGILLIPP QAQELGIPLT PQQAQALGIP LIPPQAQELG IPLTPQQVQA LGIPLIPPQA
  1561  QELEIPLTPQ QAQALGIPLT PQQAQELGIP LTPQQAQELG IPLTPQQAQA QGIPLTPQQA
  1621  QALGISLTPQ QAQAQGITLT PQQAQALGVP ITPVNAWVSA VTLTSEQTHA LESPMNLEQA
  1681  QEQLLKLGVP LTLDKAHTLG SPLTLKQVQW SHRPFQKSKA SLPTGQSIIS RLSPSLRLSL
  1741  ASSAPTAEKS SIFGVSSTPL QISRVPLNQG PFAPGKPLEM GILSEPGKLG APQTLRSSGQ
  1801  TLVYGGQSTS AQFPAPQAPP SPGQLPISRA PPTPGQPFIA GVPPTSGQIP SLWAPLSPGQ
  1861  PLVPEASSIP GDLLESGPLT FSEQLQEFQP PATAEQSPYL QAPSTPGQHL ATWTLPGRAS
  1921  SLWIPPTSRH PPTLWPSPAP GKPQKSWSPS VAKKRLAIIS SLKSKSVLIH PSAPDFKVAQ
  1981  VPFTTKKFQM SEVSDTSEET QILRDTFAIE SFRTFQSHFT KYRTPVYQTP YTDERALLTL
  2041  MKPTTSPSSL TTLLRTSQIS PLEWYQKSRF PPIDKPWILS SVSDTKKPKV MVPPSSPQEL
  2101  EEKRYFVDVE AQKKNLILLN QAIKTCGLPS QLHTMARTLI IEILHMDTVQ LGYLFRKYIA
  2161  YRLIQHARNN IMKRLKAIQN TGKGYEARNL HMMLSRLDDY GKKVMQVWTE KQKSLGQKRN
  2221  QCLKKMIHVF NQLKKIHELN LSQPIPLIIE EKQIPASTTF VQKPFLKLLM EEDRTSDICK
  2281  KFRQQEDQTE AIWNVDLSTS SYPIAEKTSM HSLWAQLGGY PDIPRLLQLE VQSTFRKSLA
  2341  SLQSRVKKIP K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM186A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
skeletal muscle: 1 nTPM
pituitary gland: 0.9 nTPM
cerebellum: 0.8 nTPM
basal ganglia: 0.7 nTPM
retina: 0.7 nTPM

Single-cell type

early spermatids: 602 nCPM
late primary spermatocytes: 188 nCPM
late spermatids: 46 nCPM
adipocytes: 24 nCPM
fibro-adipogenic progenitors: 21 nCPM
cardiomyocytes: 18 nCPM

Immune cell

basophil: 0.5 nTPM
neutrophil: 0.5 nTPM
classical monocyte: 0.3 nTPM
NK-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
gdT-cell: 0.2 nTPM

Brain region

cerebellum: 5.2 nTPM
white matter: 5.2 nTPM
cerebral cortex: 4.9 nTPM
basal ganglia: 4.6 nTPM
thalamus: 4.3 nTPM
amygdala: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 3.49
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM186A as an antibody target. Whether an autoantibody or antibody against FAM186A could matter depends on whether native FAM186A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM186A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM186A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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