Seroatlas · Human Serome Atlas

FAM185A

Protein FAM185A

Also known as: F185A_HUMAN, MGC35361

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N0U4
Gene: FAM185A
Ensembl: ENSG00000222011
Chromosome: 7
Canonical length: 392 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q8N0U4|FAM185A
     1  MLAPCSGWEL GCFRLCLRQV RLWAGAGRWA CWACQARPYS SGGSERWPGS ETEVPPPGPG
    61  RRTLKEWTLQ VSPFGRLRAR LPCHLAVRPL DPLTYPDGDR VLVAVCGVEG GVRGLDGLQV
   121  KYDEDLEEMA IVSDTIHPQA SVEVNAPLKF GLDIKSSGSG CVKVQSIEGD NCKIETEHGT
   181  SILQSVKGQK LHVQTKGGKV ICLGTVYGNI DIHASDKSAV TIDKLQGSSV TVSTEDGLLK
   241  AKYLYTESSF LSSAAGDITL GSVHGNITLQ SKMGNITVDS SSGCLKASTN QGAIDVYVSQ
   301  LGKVELKSHK GSIIVKVPSS LQAHLQLSGK EVDVNSEVHV QEMAEVRKDD VVTVTGLMNQ
   361  ASKREKWIKA DAPKGTVSFR RQSWFQSLKL QD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM185A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 3.5 nTPM
liver: 2.6 nTPM
stomach: 1.9 nTPM
tongue: 1.8 nTPM
heart muscle: 1.4 nTPM
parathyroid gland: 1.4 nTPM

Single-cell type

epicardial cells: 252 nCPM
myonuclei: 109 nCPM
distal convoluted tubule cells: 93 nCPM
podocytes: 87 nCPM
proximal tubule cells: 87 nCPM
renal connecting tubule cells: 78 nCPM

Immune cell

neutrophil: 3.3 nTPM
memory B-cell: 2.3 nTPM
eosinophil: 1.9 nTPM
myeloid DC: 1.6 nTPM
classical monocyte: 1.5 nTPM
intermediate monocyte: 1.2 nTPM

Brain region

cerebellum: 4.5 nTPM
white matter: 4.4 nTPM
cerebral cortex: 4.2 nTPM
amygdala: 3.7 nTPM
basal ganglia: 3.7 nTPM
midbrain: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.04
gnomAD missense Z: 1.48
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Toastrack DUF4097
Toastrack DUF4097

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM185A as an antibody target. Whether an autoantibody or antibody against FAM185A could matter depends on whether native FAM185A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM185A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM185A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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