Seroatlas · Human Serome Atlas

FAM184B

Protein FAM184B

Also known as: F184B_HUMAN, KIAA1276

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULE4
Gene
FAM184B
Ensembl
ENSG00000047662
Chromosome
4
Canonical length
1060 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM184B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1060 residues, UniProt reviewed canonical sequence.

>Q9ULE4|FAM184B
     1  MASALNSKIN PPGTCQGSKA DGGAGWRMDC DPQMHVKMCK KIAQLTKVIY ALNTRQDEAE
    61  ASMEALREAH QEELQNAVAE TKARLLQEQG CAEEEALLQR IQALESALEL QKRLTEEALA
   121  ESASCRLETK ERELRVEAEH AERVLTLSRE MLELKADYER RLQHLTSHEA TPQGRLPQES
   181  PETKSEPGQG PEMQEVLLEV QRLRVENQQL SKDYARKAEE LQATYERENE AIRQAMQQSV
   241  SQALWQWQEK ESDLRKNFQV QESALQAQVR KLEGDLEHRG RKISDLKKYA QKLKERIQDL
   301  DVQLKEARQE NSELKGTAKK LGEKLAVAKD RMMLQECRGT QQTDAMKTEL VSENKVLREE
   361  NDLEAGNLHP QQDQSCLKEC PCMKGGTDMQ TKKEASAETE YMKQQYEEDL RKIKHQTEEE
   421  KKHLKDQLVK RLEDLVKKHT VEIKSVRSSV EAERKKLQRE VEAQLEEVRK KSEKEIKQLE
   481  EEKAALNVKL QNSLLEVLRL EEFIQQNKTR PTGAEESPQE LGRQHCSILE TQDPCLKLDE
   541  TSPRGEEYQD KLAAEEGTSS DEEERTKVLL KEGSDPQPPL GSLLKEKTSK IQRLEEDWQS
   601  QKAKLQAQVS QMQQALEQCT SNYREDLQAL KQLSDLEREK LQRELQETTQ QNHAMKAQLE
   661  ASHQRALRML EKARHQELKA TEERLKKESS HSLQIQHQTH RLELQALEEK ARQELQEERE
   721  RMQAQQALLL ESLRQELSEQ QAACSGHQKD LEALQAELRA LGRQQASSQC PGDSKDHIIA
   781  TEERGGPGQA GSPPGAAGQG SGEGCGLWEE NAQLQDAVRR LRAEVEQHQQ EAQKLRDQRR
   841  FLEETQQAQR AREVETLRQE HRKEMQAMVA DFSSAQAQLQ ARLAALEAEL KDSGEKPGKG
   901  ASRPEDLQLI GRLQTRLKER EDIIKQLTEE RRFHYAAFPS AMSHRNRSFS FNPHPGYLTP
   961  SMKKKKVEDV PSRVVSVPNL ASYAKNFLSG DLSSRINAPP ITTSPSLDPS PSCGRTYKPN
  1021  QSTDAKTATR TPDGETAQAK EVQQKQGSPH QEWFTKYFSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM184B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
3.9 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 3.9 nTPM
  • basal ganglia: 1.8 nTPM
  • retina: 1.6 nTPM
  • cerebral cortex: 1.4 nTPM
  • hippocampal formation: 1.4 nTPM
  • amygdala: 1.2 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 174 nCPM
  • oocytes: 166 nCPM
  • myonuclei: 110 nCPM
  • oligodendrocyte progenitor cells: 99 nCPM
  • epicardial cells: 93 nCPM
  • thymic myoid cells: 88 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 5.7 nTPM
  • cerebral cortex: 5.4 nTPM
  • basal ganglia: 5.3 nTPM
  • hippocampal formation: 5.3 nTPM
  • amygdala: 5.1 nTPM
  • pons: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
1.12
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM184B as an antibody target. Whether an autoantibody or antibody against FAM184B could matter depends on whether native FAM184B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM184B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM184B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM184B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...