Seroatlas · Human Serome Atlas

FAM184A

Protein FAM184A

Also known as: C6orf60, F184A_HUMAN, FLJ13942

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NB25
Gene: FAM184A
Ensembl: ENSG00000111879
Chromosome: 6
Canonical length: 1140 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Centriolar satellite,Basal body,Cytosol

OverviewNCBI Gene

Located in several cellular components, including P-body; cytosol; and microtubule organizing center. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1140 residues, UniProt reviewed canonical sequence.

>Q8NB25|FAM184A
     1  MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ LTKVIYALNT
    61  KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE ELDLRRKIQV LESSLEDHIK
   121  MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR IVTMSREVEE IRRKFEEKLR SFGQLQVQFE
   181  KDKRLALEDL QAAHRREIQE LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE
   241  RKKLIEDYEG KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK
   301  TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG EMALLSKHKE
   361  VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI KDLESEKSRV NERLSQLEEE
   421  RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK RTQQEYYERE LKNLQSRLEE EVTQLNEAHS
   481  KTLEELAWKH HMAIEAVHSN AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV
   541  LEDKLNTANQ EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA
   601  LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS KLREELRLQH
   661  EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL KQNLEIQLSQ SQTSLQQLQA
   721  QFTQERQRLT QELEELEEQH QQRHKSLKEA HVLAFQTMEE EKEKEQRALE NHLQQKHSAE
   781  LQSLKDAHRE SMEGFRIEME QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH
   841  HQELAAAKME LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL
   901  TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI MRADFNKTNE
   961  LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML TERDQIIKKL IEDNKFYQLE
  1021  LVNRETNFNK VFNSSPTVGV INPLAKQKKK NDKSPTNRFV SVPNLSALES GGVGNGHPNR
  1081  LDPIPNSPVH DIEFNSSKPL PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM184A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

placenta: 22 nTPM
cerebral cortex: 19 nTPM
basal ganglia: 18 nTPM
amygdala: 18 nTPM
choroid plexus: 17 nTPM
testis: 16 nTPM

Single-cell type

syncytiotrophoblasts: 794 nCPM
ependymal cells: 471 nCPM
bergmann glia: 335 nCPM
astrocytes: 327 nCPM
pituicytes/fscs: 305 nCPM
corticotrophs: 293 nCPM

Immune cell

T-reg: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 33 nTPM
basal ganglia: 31 nTPM
cerebral cortex: 30 nTPM
white matter: 26 nTPM
amygdala: 24 nTPM
hippocampal formation: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.13
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM184A as an antibody target. Whether an autoantibody or antibody against FAM184A could matter depends on whether native FAM184A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM184A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM184A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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