Seroatlas · Human Serome Atlas

FAM181B

Protein FAM181B

Also known as: F181B_HUMAN, LOC220382, MGC33846

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NEQ2
Gene: FAM181B
Ensembl: ENSG00000182103
Chromosome: 11
Canonical length: 426 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Mitochondria

OverviewNCBI Gene

No narrative summary is available for FAM181B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>A6NEQ2|FAM181B
     1  MAVQAALLST HPFVPFGFGG SPDGLGGAFG ALDKGCCFED DETGAPAGAL LSGAEGGDVR
    61  EATRDLLSFI DSASSNIKLA LDKPGKSKRK VNHRKYLQKQ IKRCSGLMGA APPGPPSPSA
   121  ADTPAKRPLA APSAPTVAAP AHGKAAPRRE ASQAAAAASL QSRSLAALFD SLRHVPGGAE
   181  PAGGEVAAPA AGLGGAGTGG AGGDVAGPAG ATAIPGARKV PLRARNLPPS FFTEPSRAGG
   241  GGCGPSGPDV SLGDLEKGAE AVEFFELLGP DYGAGTEAAV LLAAEPLDVF PAGASVLRGP
   301  PELEPGLFEP PPAVVGNLLY PEPWSVPGCS PTKKSPLTAP RGGLTLNEPL SPLYPAAADS
   361  PGGEDGRGHL ASFAPFFPDC ALPPPPPPHQ VSYDYSAGYS RTAYSSLWRS DGVWEGAPGE
   421  EGAHRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM181B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

amygdala: 20 nTPM
midbrain: 19 nTPM
spinal cord: 17 nTPM
cerebral cortex: 17 nTPM
hippocampal formation: 16 nTPM
basal ganglia: 15 nTPM

Single-cell type

bergmann glia: 323 nCPM
astrocytes: 84 nCPM
ependymal cells: 66 nCPM
oligodendrocyte progenitor cells: 56 nCPM
schwann cells: 36 nCPM
epididymal efferent duct ciliated cells: 32 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 58 nTPM
spinal cord: 53 nTPM
white matter: 50 nTPM
midbrain: 46 nTPM
basal ganglia: 44 nTPM
thalamus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0.07
gnomAD missense Z: 0.09
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM181B as an antibody target. Whether an autoantibody or antibody against FAM181B could matter depends on whether native FAM181B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM181B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM181B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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