Seroatlas · Human Serome Atlas

FAM181A

Protein FAM181A

Also known as: C14orf152, F181A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9Y4
Gene: FAM181A
Ensembl: ENSG00000140067
Chromosome: 14
Canonical length: 354 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q8N9Y4|FAM181A
     1  MPLEERRSSG ERNDAAPTNH RRPGEKRAST AKQVSSVPFL GAAGHQQSLP SSWKASCSGP
    61  LVMASDSDVK MLLNFVNLAS SDIKAALDKS APCRRSVDHR KYLQKQLKRF SQKYSRLPRG
   121  LPGRAAEPYL KRGSEDRPRR LLLDLGPDSS PGGGGGCKEK VLRNPYREEC LAKEQLPQRQ
   181  HPEAAQPGQV PMRKRQLPAS FWEEPRPTHS YHVGLEGGLG PREGPPYEGK KNCKGLEPLG
   241  PETTLVSMSP RALAEKEPLK MPGVSLVGRV NAWSCCPFQY HGQPIYPGPL GALPQSPVPS
   301  LGLWRKSPAF PGELAHLCKD VDGLGQKVCR PVVLKPIPTK PAVPPPIFNV FGYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM181A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

testis: 32 nTPM
amygdala: 14 nTPM
cerebral cortex: 12 nTPM
hippocampal formation: 9.7 nTPM
basal ganglia: 9.5 nTPM
hypothalamus: 9.4 nTPM

Single-cell type

ependymal cells: 21 nCPM
bergmann glia: 13 nCPM
astrocytes: 10 nCPM
other brain neurons: 0.9 nCPM
brain excitatory neurons: 0.5 nCPM
brain inhibitory neurons: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 10 nTPM
hypothalamus: 8.5 nTPM
spinal cord: 7.8 nTPM
midbrain: 7.7 nTPM
thalamus: 6.8 nTPM
amygdala: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM181A as an antibody target. Whether an autoantibody or antibody against FAM181A could matter depends on whether native FAM181A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM181A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM181A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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