Seroatlas · Human Serome Atlas

FAM180B

Protein FAM180B

Also known as: F180B_HUMAN, LOC399888

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P0A1
Gene
FAM180B
Ensembl
ENSG00000196666
Chromosome
11
Canonical length
183 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q6P0A1|FAM180B
     1  MAATLQFLVC LVVAICLLSG VTTTQPHAGQ PMDSTSVGGG LQEPEAPEVM FELLWAGLEL
    61  DVMGQLHIQD EELASTHPGR RLRLLLQHHV PSDLEGTEQW LQQLQDLRKG PPLSTWDFEH
   121  LLLTGLSCVY RLHAASEAEE RGRWAQVFAL LAQETLWDLC KGFCPQDRPP SLGSWASILD
   181  PFP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM180B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 26 nTPM
  • adipose tissue: 6.1 nTPM
  • skin: 5.9 nTPM
  • breast: 4.8 nTPM
  • thyroid gland: 4 nTPM
  • blood vessel: 3.2 nTPM

Single-cell type

  • microglia: 3.6 nCPM
  • astrocytes: 1.3 nCPM
  • bergmann glia: 1.2 nCPM
  • choroid plexus epithelial cells: 1 nCPM
  • ependymal cells: 0.6 nCPM
  • brain excitatory neurons: 0.2 nCPM

Immune cell

  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 21 nTPM
  • choroid plexus: 20 nTPM
  • white matter: 14 nTPM
  • medulla oblongata: 13 nTPM
  • basal ganglia: 13 nTPM
  • thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
0.99

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM180B as an antibody target. Whether an autoantibody or antibody against FAM180B could matter depends on whether native FAM180B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM180B is annotated as secreted, so native FAM180B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM180B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM180B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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