Seroatlas · Human Serome Atlas

FAM180A

Protein FAM180A

Also known as: F180A_HUMAN, HWKM1940, UNQ1940

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWF9
Gene
FAM180A
Ensembl
ENSG00000189320
Chromosome
7
Canonical length
173 aa
Protein class
Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>Q6UWF9|FAM180A
     1  MHWKMLLLLL LYYNAEASMC HRWSRAVLFP AAHRPKRSSS LPLNPVLQTS LEEVELLYEF
    61  LLAELEISPD LQISIKDEEL ASLRKASDFR TVCNNVIPKS IPDIRRLSAS LSSHPGILKK
   121  EDFERTVLTL AYTAYRTALS HGHQKDIWAQ SLVSLFQALR HDLMRSSQPG VPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM180A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 35 nTPM
  • gallbladder: 15 nTPM
  • heart muscle: 15 nTPM
  • liver: 9.6 nTPM
  • ovary: 5.6 nTPM
  • endometrium: 4.4 nTPM

Single-cell type

  • hepatic stellate cells: 142 nCPM
  • podocytes: 127 nCPM
  • fibroblasts: 40 nCPM
  • fibro-adipogenic progenitors: 15 nCPM
  • cardiomyocytes: 13 nCPM
  • ovarian stromal cells: 9.9 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 9.7 nTPM
  • hippocampal formation: 1.5 nTPM
  • cerebral cortex: 1.4 nTPM
  • basal ganglia: 1.2 nTPM
  • cerebellum: 1.1 nTPM
  • white matter: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
-0.2
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM180A as an antibody target. Whether an autoantibody or antibody against FAM180A could matter depends on whether native FAM180A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM180A is annotated as secreted, so native FAM180A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM180A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM180A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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