Seroatlas · Human Serome Atlas

FAM178B

Protein FAM178B

Also known as: F178B_HUMAN, LOC51252

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXR5
Gene: FAM178B
Ensembl: ENSG00000168754
Chromosome: 2
Canonical length: 679 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for FAM178B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

679 residues, UniProt reviewed canonical sequence.

>Q8IXR5|FAM178B
     1  MWPRLPGAGL APQLRRQDQR LHFTGQMSHG LQMAGPQETV LALPLREGVQ AAATVPILLY
    61  NLEDGLSDHP LDQGPRCPAR RPCSPASAPA PTSPKKPKIQ APGETFPTDW SPPPVEFLNP
   121  RVLQASREAP AQRWVGVVGP QGLRRLAGEL PEELEQEHLD LDPKRGLALP EKLFWNTSGL
   181  SQQAAAPEFS WGGSGSYFNN LDYLLQEKRE QALEQERERL LLQECLNLNS LDLDEEEVPL
   241  TPEHRMLVEK YSVSLQTIPP VHPGETVFLP RCHPLPCILD SSLLKPRSHL EGLFLSSPPA
   301  QQLSFLRSGL LNILYLHMPD CPVSLLQWLF QLLTWPPETS LGAFGLLWDL IVDGIFLQPD
   361  EDKHLWCPSL QEVREAFHSL GAHSPALYPL GPFWHGGRVL PGEAGLNENE EQDAPQEIAL
   421  DISLGHIYKF LALCAQAQPG AYTDENLMGL IELLCRTSLD VGLRLLPKVD LQQLLLLLLE
   481  NIREWPGKLQ ELCCTLSWVS DHHHNLLALV QFFPDMTSRS RRLRSQLSLV VIARMLGQQE
   541  MLPLWQEKTQ LSSLSRLLGL MRPSSLRQYL DSVPLPPCQE QQPKASAELD HKACYLCHSL
   601  LMLAGVVVSC QDITPDQWGE LQLLCMQLDR HISTQIRESP QAMHRTMLKD LATQTYIRWQ
   661  ELLTHCQPQA QYFSPWKDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM178B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 18 nTPM
spinal cord: 16 nTPM
spleen: 11 nTPM
midbrain: 9.7 nTPM
testis: 7.8 nTPM
basal ganglia: 6.3 nTPM

Single-cell type

erythrocyte progenitors: 397 nCPM
epididymal principal cells: 115 nCPM
undifferentiated spermatogonia: 75 nCPM
differentiating spermatogonia: 72 nCPM
megakaryocyte-erythroid progenitors: 50 nCPM
melanocytes: 42 nCPM

Immune cell

gdT-cell: 0.5 nTPM
naive CD4 T-cell: 0.5 nTPM
naive CD8 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
total PBMC: 0.1 nTPM

Brain region

white matter: 17 nTPM
basal ganglia: 14 nTPM
midbrain: 13 nTPM
medulla oblongata: 12 nTPM
pons: 11 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM178B as an antibody target. Whether an autoantibody or antibody against FAM178B could matter depends on whether native FAM178B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM178B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM178B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...