FAM177B
Protein FAM177B
Also known as: F177B_HUMAN, FLJ43505, RP11-452F19.2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6PVY3
- Gene
- FAM177B
- Ensembl
- ENSG00000197520
- Chromosome
- 1
- Canonical length
- 158 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mid piece
OverviewNCBI Gene
No narrative summary is available for FAM177B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
158 residues, UniProt reviewed canonical sequence.
>A6PVY3|FAM177B
1 MEIDGFQQLD LEKSVPSKKT TPKRIIHFVD GDIMEEYSTE EEEEEEKEEQ STNSTLDPSK
61 LSWGPYLRFW AGRIASTSFS TCEFLGGRFA VFFGLTQPKY QYVLNEFYRI QNKKSDNKSE
121 RRGSKAQAAE VPNEKCHLEA GVQEYGTIQQ DVTEAIPQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM177B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 43 nTPM
Expression across tissuesHPA
Tissue
- stomach: 43 nTPM
- small intestine: 8.7 nTPM
- rectum: 7.8 nTPM
- gallbladder: 7.6 nTPM
- tonsil: 7.1 nTPM
- lymph node: 7 nTPM
Single-cell type
- foveolar cells: 267 nCPM
- goblet cells: 258 nCPM
- microglia: 188 nCPM
- b-cells: 80 nCPM
- epididymal basal cells: 53 nCPM
- monocytes: 52 nCPM
Immune cell
- naive B-cell: 50 nTPM
- memory B-cell: 40 nTPM
- plasmacytoid DC: 2.3 nTPM
- total PBMC: 1.1 nTPM
- neutrophil: 0.9 nTPM
- eosinophil: 0.3 nTPM
Brain region
- medulla oblongata: 7.5 nTPM
- thalamus: 6.7 nTPM
- amygdala: 6.1 nTPM
- pons: 5.6 nTPM
- hippocampal formation: 5 nTPM
- midbrain: 4.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.61
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.42
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM177B as an antibody target. Whether an autoantibody or antibody against FAM177B could matter depends on whether native FAM177B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM177B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM177B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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