Seroatlas · Human Serome Atlas

FAM174C

Protein FAM174C

Also known as: C19orf24, F174C_HUMAN, FLJ20640

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVV8
Gene
FAM174C
Ensembl
ENSG00000228300
Chromosome
19
Canonical length
132 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear speckles,Golgi apparatus

OverviewNCBI Gene

Located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q9BVV8|FAM174C
     1  MGPRVLQPPL LLLLLALLLA ALPCGAEEAS PLRPAQVTLS PPPAVTNGSQ PGAPHNSTHT
    61  RPPGASGSAL TRSFYVILGF CGLTALYFLI RAFRLKKPQR RRYGLLANTE DPTEMASLDS
   121  DEETVFESRN LR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM174C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
124 nTPM

Expression across tissuesHPA

Tissue

  • liver: 124 nTPM
  • adrenal gland: 73 nTPM
  • pancreas: 56 nTPM
  • spleen: 54 nTPM
  • choroid plexus: 53 nTPM
  • esophagus: 53 nTPM

Single-cell type

  • late spermatids: 574 nCPM
  • esophageal suprabasal cells: 204 nCPM
  • esophageal basal cells: 185 nCPM
  • extravillous trophoblasts: 185 nCPM
  • epididymal principal cells: 174 nCPM
  • oocytes: 170 nCPM

Immune cell

  • plasmacytoid DC: 166 nTPM
  • memory B-cell: 154 nTPM
  • naive B-cell: 138 nTPM
  • T-reg: 122 nTPM
  • memory CD4 T-cell: 115 nTPM
  • memory CD8 T-cell: 114 nTPM

Brain region

  • choroid plexus: 34 nTPM
  • pons: 33 nTPM
  • medulla oblongata: 32 nTPM
  • thalamus: 32 nTPM
  • basal ganglia: 30 nTPM
  • cerebellum: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM174C as an antibody target. Whether an autoantibody or antibody against FAM174C could matter depends on whether native FAM174C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM174C is annotated as secreted, so native FAM174C circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM174C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM174C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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