Seroatlas · Human Serome Atlas

FAM174B

Membrane protein FAM174B

Also known as: F174B_HUMAN, LOC400451, MGC102891

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3ZCQ3
Gene
FAM174B
Ensembl
ENSG00000185442
Chromosome
15
Canonical length
159 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Intermediate filaments

OverviewNCBI Gene

Involved in Golgi organization. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>Q3ZCQ3|FAM174B
     1  MRAVPLPAPL LPLLLLALLA APAARASRAE SVSAPWPEPE RESRPPPGPG PGNTTRFGSG
    61  AAGGSGSSSS NSSGDALVTR ISILLRDLPT LKAAVIVAFA FTTLLIACLL LRVFRSGKRL
   121  KKTRKYDIIT TPAERVEMAP LNEEDDEDED STVFDIKYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM174B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 75 nTPM
  • salivary gland: 49 nTPM
  • thyroid gland: 35 nTPM
  • stomach: 35 nTPM
  • prostate: 30 nTPM
  • pituitary gland: 26 nTPM

Single-cell type

  • neutrophils: 219 nCPM
  • alveolar cells type 1: 217 nCPM
  • transitional alveolar cells: 176 nCPM
  • retinal pigment epithelial cells: 162 nCPM
  • prostatic hillock cells: 145 nCPM
  • prostatic club cells: 123 nCPM

Immune cell

  • T-reg: 8.9 nTPM
  • plasmacytoid DC: 3.5 nTPM
  • neutrophil: 2.9 nTPM
  • naive CD8 T-cell: 2.6 nTPM
  • naive CD4 T-cell: 2 nTPM
  • memory CD4 T-cell: 1.8 nTPM

Brain region

  • white matter: 37 nTPM
  • midbrain: 32 nTPM
  • hypothalamus: 29 nTPM
  • pons: 28 nTPM
  • hippocampal formation: 27 nTPM
  • cerebral cortex: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0
gnomAD missense Z
-0.85
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM174B as an antibody target. Whether an autoantibody or antibody against FAM174B could matter depends on whether native FAM174B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM174B is annotated at the cell surface, where native FAM174B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FAM174B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM174B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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