Seroatlas · Human Serome Atlas

FAM171B

Protein FAM171B

Also known as: F171B_HUMAN, FLJ34104, KIAA1946

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P995
Gene
FAM171B
Ensembl
ENSG00000144369
Chromosome
2
Canonical length
826 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Nucleoli,Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

826 residues, UniProt reviewed canonical sequence.

>Q6P995|FAM171B
     1  MARLCRRVPC TLLLGLAVVL LKARLVPAAA RAELSRSDLS LIQQQQQQQQ QQQQQQKQLE
    61  EAEEERTEVP GATSTLTVPV SVFMLKVQVN DIISRQYLSQ AVVEVFVNYT KTNSTVTKSN
   121  GAVLIKVPYK LGLSLTIIAY KDGYVLTPLP WKTRRMPIYS SVTLSLFPQS QANIWLFEDT
   181  VLITGKLADA KSQPSVQFSK ALIKLPDNHH ISNVTGYLTV LQQFLKVDNF LHTTGITLNK
   241  PGFENIELTP LAAICVKIYS GGKELKVNGS IQVSLPLLRL NDISAGDRIP AWTFDMNTGA
   301  WVNHGRGMVK EHNNHLIWTY DAPHLGYWIA APLPGTRGSG INEDSKDITA YHTVFLTAIL
   361  GGTIVIVIGF FAVLLCYCRD KCGTPQKRER NITKLEVLKR DQTTSTTHIN HISTVKVALK
   421  AEDKSQLFNA KNSSYSPQKK EPSKAETEER VSMVKTRDDF KIYNEDVSFL SVNQNNYSRN
   481  PTQSLEPNVG SKQPKHINNN LSSSLGDAQD EKRYLTGNEE AYGRSHIPEQ LMHIYSQPIA
   541  ILQTSDLFST PEQLHTAKSA TLPRKGQLVY GQLMEPVNRE NFTQTLPKMP IHSHAQPPDA
   601  REEDIILEGQ QSLPSQASDW SRYSSSLLES VSVPGTLNEA VVMTPFSSEL QGISEQTLLE
   661  LSKGKPSPHP RAWFVSLDGK PVAQVRHSFI DLKKGKRTQS NDTSLDSGVD MNELHSSRKL
   721  EREKTFIKSM HQPKILYLED LDLSSSESGT TVCSPEDPAL RHILDGGSGV IMEHPGEESP
   781  GRKSTVEDFE ANTSPTKRRG RPPLAKRDSK TNIWKKREER PLIPIN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM171B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 66 nTPM
  • basal ganglia: 35 nTPM
  • amygdala: 32 nTPM
  • retina: 22 nTPM
  • hippocampal formation: 22 nTPM
  • salivary gland: 22 nTPM

Single-cell type

  • astrocytes: 388 nCPM
  • retinal bipolar cells: 329 nCPM
  • adrenal medulla cells: 277 nCPM
  • bergmann glia: 234 nCPM
  • somatotrophs: 186 nCPM
  • thyrotrophs: 184 nCPM

Immune cell

  • NK-cell: 0.4 nTPM
  • intermediate monocyte: 0.3 nTPM
  • non-classical monocyte: 0.3 nTPM
  • basophil: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • cerebral cortex: 133 nTPM
  • basal ganglia: 127 nTPM
  • hippocampal formation: 120 nTPM
  • amygdala: 103 nTPM
  • hypothalamus: 95 nTPM
  • white matter: 90 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.49
gnomAD missense Z
1.51
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM171B as an antibody target. Whether an autoantibody or antibody against FAM171B could matter depends on whether native FAM171B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM171B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM171B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM171B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...