Seroatlas · Human Serome Atlas

FAM170A

Protein FAM170A

Also known as: F170A_HUMAN, ZNFD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1A519
Gene: FAM170A
Ensembl: ENSG00000164334
Chromosome: 5
Canonical length: 330 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Involved in positive regulation of DNA-templated transcription and transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>A1A519|FAM170A
     1  MKRRQKRKHL ENEESQETAE KGGGMSKSQE DALQPGSTRV AKGWSQGVGE VTSTSEYCSC
    61  VSSSRKLIHS GIQRIHRDSP QPQSPLAQVQ ERGETPPRSQ HVSLSSYSSY KTCVSSLCVN
   121  KEERGMKIYY MQVQMNKGVA VSWETEETLE SLEKQPRMEE VTLSEVVRVG TPPSDVSTRN
   181  LLSDSEPSGE EKEHEERTES DSLPGSPTVE DTPRAKTPDW LVTMENGFRC MACCRVFTTM
   241  EALQEHVQFG IREGFSCHVF HLTMAQLTGN MESESTQDEQ EEENGNEKEE EEKPEAKEEE
   301  GQPTEEDLGL RRSWSQCPGC VFHSPKDRNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM170A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
choroid plexus: 0.2 nTPM
liver: 0.1 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late primary spermatocytes: 96 nCPM
late spermatids: 15 nCPM
early spermatids: 12 nCPM
early primary spermatocytes: 2.8 nCPM
endometrial ciliated cells: 1.5 nCPM
differentiating spermatogonia: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.4 nTPM
medulla oblongata: 0.3 nTPM
white matter: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM170A as an antibody target. Whether an autoantibody or antibody against FAM170A could matter depends on whether native FAM170A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM170A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM170A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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