FAM167B
Protein FAM167B
Also known as: C1orf90, DIORA-2, F167B_HUMAN, MGC10820
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BTA0
- Gene
- FAM167B
- Ensembl
- ENSG00000183615
- Chromosome
- 1
- Canonical length
- 163 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Actin filaments
OverviewNCBI Gene
No narrative summary is available for FAM167B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
163 residues, UniProt reviewed canonical sequence.
>Q9BTA0|FAM167B
1 MSLGLLKFQA VGEEDEEDEE GESLDSVKAL TAKLQLQTRR PSYLEWTAQV QSQAWRRAQA
61 KPGPGGPGDI CGFDSMDSAL EWLRRELREM QAQDRQLAGQ LLRLRAQLHR LKMDQACHLH
121 QELLDEAELE LELEPGAGLA LAPLLRHLGL TRMNISARRF TLCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM167B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 44 nTPM
Expression across tissuesHPA
Tissue
- kidney: 44 nTPM
- adrenal gland: 20 nTPM
- lung: 20 nTPM
- thyroid gland: 19 nTPM
- adipose tissue: 19 nTPM
- prostate: 16 nTPM
Single-cell type
- vascular endothelial cells: 93 nCPM
- hepatic stellate cells: 19 nCPM
- decidual stromal cells: 12 nCPM
- tuft cells: 12 nCPM
- melanocytes: 11 nCPM
- breast secretory cells: 4.9 nCPM
Immune cell
- T-reg: 1.7 nTPM
- gdT-cell: 0.8 nTPM
- naive CD8 T-cell: 0.5 nTPM
- naive B-cell: 0.3 nTPM
- eosinophil: 0.2 nTPM
- MAIT T-cell: 0.2 nTPM
Brain region
- thalamus: 4.9 nTPM
- hypothalamus: 4.3 nTPM
- pons: 4 nTPM
- medulla oblongata: 3.9 nTPM
- choroid plexus: 3.8 nTPM
- spinal cord: 3.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.65
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.37
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM167B as an antibody target. Whether an autoantibody or antibody against FAM167B could matter depends on whether native FAM167B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM167B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM167B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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