Seroatlas · Human Serome Atlas

FAM163B

Protein FAM163B

Also known as: C9orf166, F163B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C2L3
Gene
FAM163B
Ensembl
ENSG00000196990
Chromosome
9
Canonical length
166 aa
Protein class
Predicted membrane proteins
Subcellular location
Nuclear bodies,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>P0C2L3|FAM163B
     1  MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKDES EEDEEEPDFA VHSHLPPLHS
    61  NRNLVLTNGP ALYPTASTSF SQKSPQARAL CRSCSHCEPP TFFLQEPPEE EEDVLNGGER
   121  VLYKSVSQED VELPPGGFGG LQALNPNRLS AMREAFARSR SISTDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM163B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 61 nTPM
  • amygdala: 16 nTPM
  • hippocampal formation: 9 nTPM
  • adrenal gland: 8.8 nTPM
  • cerebellum: 7.5 nTPM
  • hypothalamus: 6.8 nTPM

Single-cell type

  • late spermatids: 51 nCPM
  • adrenal medulla cells: 32 nCPM
  • brain inhibitory neurons: 28 nCPM
  • hepatic stellate cells: 26 nCPM
  • brain excitatory neurons: 22 nCPM
  • early spermatids: 20 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 171 nTPM
  • white matter: 120 nTPM
  • basal ganglia: 118 nTPM
  • pons: 66 nTPM
  • amygdala: 58 nTPM
  • hippocampal formation: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0.03
gnomAD missense Z
-0.76
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM163B as an antibody target. Whether an autoantibody or antibody against FAM163B could matter depends on whether native FAM163B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM163B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM163B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM163B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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