Seroatlas · Human Serome Atlas

FAM163A

Protein FAM163A

Also known as: C1orf76, F163A_HUMAN, MGC16664, NDSP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GL9
Gene
FAM163A
Ensembl
ENSG00000143340
Chromosome
1
Canonical length
167 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q96GL9|FAM163A
     1  MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKSGT EVADEEEERE HDLPTHPRGP
    61  TCNACSSQAL DGRGSLAPLT SEPCSQPCGV AASHCTTCSP YSSPFYIRTA DMVPNGGGGE
   121  RLSFAPTYYK EGGPPSLKLA APQSYPVTWP GSGREAFTNP RAISTDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM163A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 30 nTPM
  • thymus: 15 nTPM
  • testis: 13 nTPM
  • adrenal gland: 5.7 nTPM
  • cerebral cortex: 2.4 nTPM
  • colon: 1.6 nTPM

Single-cell type

  • lactotrophs: 923 nCPM
  • somatotrophs: 490 nCPM
  • adrenal medulla cells: 160 nCPM
  • late spermatids: 126 nCPM
  • early spermatids: 117 nCPM
  • gonadotrophs: 106 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 44 nTPM
  • thalamus: 24 nTPM
  • medulla oblongata: 21 nTPM
  • basal ganglia: 10 nTPM
  • cerebral cortex: 9.9 nTPM
  • midbrain: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0.12
gnomAD missense Z
0.66
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM163A as an antibody target. Whether an autoantibody or antibody against FAM163A could matter depends on whether native FAM163A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM163A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM163A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM163A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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