Seroatlas · Human Serome Atlas

FAM162B

Protein FAM162B

Also known as: bA86F4.2, C6orf189, F162B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T6X4
Gene
FAM162B
Ensembl
ENSG00000183807
Chromosome
6
Canonical length
162 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

162 residues, UniProt reviewed canonical sequence.

>Q5T6X4|FAM162B
     1  MLRAVGSLLR LGRGLTVRCG PGAPLEATRR PAPALPPRGL PCYSSGGAPS NSGPQGHGEI
    61  HRVPTQRRPS QFDKKILLWT GRFKSMEEIP PRIPPEMIDT ARNKARVKAC YIMIGLTIIA
   121  CFAVIVSAKR AVERHESLTS WNLAKKAKWR EEAALAAQAK AK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM162B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 61 nTPM
  • lung: 17 nTPM
  • adipose tissue: 14 nTPM
  • adrenal gland: 14 nTPM
  • seminal vesicle: 13 nTPM
  • cervix: 12 nTPM

Single-cell type

  • salivary ionocytes: 298 nCPM
  • pericytes: 207 nCPM
  • adrenal medulla cells: 160 nCPM
  • vascular smooth muscle cells: 58 nCPM
  • fibro-adipogenic progenitors: 49 nCPM
  • decidual stromal cells: 35 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 11 nTPM
  • white matter: 8.3 nTPM
  • basal ganglia: 7.2 nTPM
  • amygdala: 4.3 nTPM
  • medulla oblongata: 4.2 nTPM
  • thalamus: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM162B as an antibody target. Whether an autoantibody or antibody against FAM162B could matter depends on whether native FAM162B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM162B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM162B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM162B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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