Seroatlas · Human Serome Atlas

FAM161B

Protein FAM161B

Also known as: C14orf44, F161B_HUMAN, FLJ31697

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MY7
Gene
FAM161B
Ensembl
ENSG00000156050
Chromosome
14
Canonical length
647 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in cilium organization. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

647 residues, UniProt reviewed canonical sequence.

>Q96MY7|FAM161B
     1  MTVGRPEGAP GGAEGSRQIF PPESFADTEA GEELSGDGLV LPRASKLDEF LSPEEEIDST
    61  SDSTGSIYQN LQELKQKGRW CLLESLFQSD PESDENLSED EEDLESFFQD KDRGMVQVQC
   121  PQALRCGSTR RCSSLNNLPS NIPRPQTQPP SGSRPPSQHR SVSSWASSIT VPRPFRMTLR
   181  EARKKAEWLG SPASFEQERQ RAQRQGEEEA ECHRQFRAQP VPAHVYLPLY QEIMERSEAR
   241  RQAGIQKRKE LLLSSLKPFS FLEKEEQLKE AARQRDLAAT AEAKISKQKA TRRIPKSILE
   301  PALGDKLQEA ELFRKIRIQM RALDMLQMAS SPIASSSNRA NPQPRTATRT QQEKLGFLHT
   361  NFRFQPRVNP VVPDYEGLYK AFQRRAAKRR ETQEATRNKP FLLRTANLRH PQRPCDAATT
   421  GRRQDSPQPP ATPLPRSRSL SGLASLSANT LPVHITDATR KRESAVRSAL EKKNKADESI
   481  QWLEIHKKKS QAMSKSVTLR AKAMDPHKSL EEVFKAKLKE NRNNDRKRAK EYKKELEEMK
   541  QRIQTRPYLF EQVAKDLAKK EAEQWYLDTL KQAGLEEDFV RNKGQGTRAV QEKETKIKDF
   601  PRFQETTKLS IRDPEQGLEG SLEQPASPRK VLEELSHQSP ENLVSLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM161B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • testis: 19 nTPM
  • cerebral cortex: 12 nTPM
  • hypothalamus: 11 nTPM
  • basal ganglia: 11 nTPM
  • ovary: 10 nTPM
  • amygdala: 10 nTPM

Single-cell type

  • late spermatids: 195 nCPM
  • early spermatids: 86 nCPM
  • breast myoepithelial cells: 35 nCPM
  • retinal ganglion cells: 35 nCPM
  • rod photoreceptor cells: 32 nCPM
  • enterocytes: 28 nCPM

Immune cell

  • basophil: 3.2 nTPM
  • eosinophil: 1.9 nTPM
  • memory CD8 T-cell: 1.7 nTPM
  • classical monocyte: 1.3 nTPM
  • MAIT T-cell: 1.3 nTPM
  • NK-cell: 1.3 nTPM

Brain region

  • cerebral cortex: 21 nTPM
  • pons: 20 nTPM
  • basal ganglia: 18 nTPM
  • white matter: 18 nTPM
  • hypothalamus: 18 nTPM
  • medulla oblongata: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
-0.61
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM161B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM161B as an antibody target. Whether an autoantibody or antibody against FAM161B could matter depends on whether native FAM161B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM161B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM161B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM161B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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