Seroatlas · Human Serome Atlas

FAM157C

Putative protein FAM157C

Also known as: F157C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CG43
Gene
FAM157C
Canonical length
387 aa

OverviewNCBI Gene

No narrative summary is available for FAM157C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>P0CG43|FAM157C
     1  MGPLFTTIPG AHSGPMRPLP KKHVEPMAVR QLLLGNATMI RHTCPMSVPL SRQVKEVAAQ
    61  KPSEDIYKNW RRQQQQQQQQ QQQQQQQQLD LLFHQRIQIS LWPRKQKRRK TEQHSHSFVK
   121  KAFRFSASPG CGRPSSNKML RSMGGGQRPT GLGSEFFRLL HDLHLLAFPT KCIWIHRRGE
   181  ATARPRAPEH PAPPATAVRG RDAASQNLKR RPGSGTDGLR LQGAEPSRLL RTYAGGAVIP
   241  TGTPERAQPP PPQDLLGRRR WLSRNTWGPW PGTTQPPSPQ LLRNDWGSCG FMVPEAARGK
   301  VFQDSQEGAH IRRETVSKSV CAEPWRHQRA RDPAPTNFPL KCQKQRGAST SSGQHGGRVN
   361  LVFFIDSPTV IAVPDLQCPT KYSGILY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM157C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM157C as an antibody target. Whether an autoantibody or antibody against FAM157C could matter depends on whether native FAM157C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM157C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM157C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM157C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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