Seroatlas · Human Serome Atlas

FAM157B

Putative protein FAM157B

Also known as: F157B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG42
Gene: FAM157B
Canonical length: 384 aa

OverviewNCBI Gene

No narrative summary is available for FAM157B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>P0CG42|FAM157B
     1  MGPLFTTIPG AHSGPMRPLP KKHVEPMAVR QLLLGNSTMI RHTCPMSVPL SRQVKEVAAQ
    61  KPSEDIYKNR QRRQQQQQQQ QQQQQLDLLF HQRIQISLWP RKQKRRKTEQ HSHPFVKKAF
   121  RFSAGPGCRR PSSNKMLRSM GGGQRPMGLG SEFFRLLHDL HLLAFATKRI WIHRRGEATA
   181  RPRAPEHPAP PATAVRGRDA ASQNLKRRPG SGTDGLRLQG AEPSRLLRTY AGGAVIPTGT
   241  PERAQPPPPQ DPLGRRRWLS RNTWGPWPGT TQPPSPQLLR NDWGSCGFMV PEAARGKVFQ
   301  DSQEGAHIRR ETVSKSVCAE PWRHQRARDP APTNFPLKCQ KQRGASTSSG QHGGRVNLVF
   361  FIDSPTVIAV PDLQCPTKYS GILY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM157B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM157B as an antibody target. Whether an autoantibody or antibody against FAM157B could matter depends on whether native FAM157B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM157B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM157B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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