Seroatlas · Human Serome Atlas

FAM157A

Putative protein FAM157A

Also known as: F157A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JC47
Gene: FAM157A
Canonical length: 383 aa

OverviewNCBI Gene

No narrative summary is available for FAM157A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>C9JC47|FAM157A
     1  MGPLFTTIPG AHSGPMRPLP KKHVEPMAVR QLLLGNSTMI RHTCPMSVPL SRQVKEVAAQ
    61  KPSEDIYKNW QQQQQQQQQQ QQQQLDLLFH QRIQISLWPR KQKRRKTEQH SHPFVKKAFR
   121  FSAGSGCGRP SSNKMLRSMG GGQRPTGLGS EFFRLLHDLH LLAFAMKRIW IHRRGEATAR
   181  PRAPEHPAPP ATAVRGRDAA SQNLKRRPGS GTDGLRLQGA EPSRLLRTYA GGAVIPTGTP
   241  ERAQPPPPQD PLGRRRWLSR NTWGPWPGTT QPPSPQLLRN DWGSCGFMVP EAARGKVFQD
   301  SQEGAHIRRE TVSKSVCAEP WRHQRARDPA PTNFPLRCQK QRGASASSGQ HEGRVNLVFF
   361  IGSPTVIAVP DLQCPTKYSG MLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM157A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM157A as an antibody target. Whether an autoantibody or antibody against FAM157A could matter depends on whether native FAM157A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM157A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM157A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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