Seroatlas · Human Serome Atlas

FAM156A

Protein FAM156A/FAM156B

Also known as: FA156_HUMAN, FAM156B, PRO0659, TMEM29, TMEM29B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NDB6
Gene
FAM156A
Ensembl
ENSG00000268350
Chromosome
X
Canonical length
213 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable methylated histone binding activity. Located in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q8NDB6|FAM156A
     1  MDPLQKRNPA SPSKSSPMTA AETSQEGPAP SQPSYSEQPM MGLSNLSPGP GPSQAVPLPE
    61  GLLRQRYREE KTLEERRWER LEFLQRKKAF LRHVRRRHRD HMAPYAVGRE ARISPLGDRS
   121  QNRFRCECRY CQSHRPNLSG IPGESNRAPH PSSWETLVQG LSGLTLSLGT NQPGPLPEAA
   181  LQPQETEEKR QRERQQESKI MFQRLLKQWL EEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM156A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • skin: 42 nTPM
  • pituitary gland: 41 nTPM
  • cerebellum: 34 nTPM
  • placenta: 30 nTPM
  • adrenal gland: 26 nTPM
  • spleen: 25 nTPM

Single-cell type

  • müller glia: 0.3 nCPM
  • podocytes: 0.3 nCPM
  • thyrotrophs: 0.3 nCPM
  • cdc: 0.1 nCPM
  • distal convoluted tubule cells: 0.1 nCPM
  • fibro-adipogenic progenitors: 0.1 nCPM

Immune cell

  • myeloid DC: 1.8 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • non-classical monocyte: 1.8 nTPM
  • classical monocyte: 1.6 nTPM
  • intermediate monocyte: 1.5 nTPM
  • memory CD8 T-cell: 1.1 nTPM

Brain region

  • choroid plexus: 38 nTPM
  • cerebral cortex: 37 nTPM
  • cerebellum: 33 nTPM
  • white matter: 30 nTPM
  • medulla oblongata: 29 nTPM
  • hypothalamus: 28 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM156A as an antibody target. Whether an autoantibody or antibody against FAM156A could matter depends on whether native FAM156A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM156A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM156A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM156A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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