Seroatlas · Human Serome Atlas

FAM153B

Protein FAM153B

Also known as: F153B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7A2
Gene: FAM153B
Canonical length: 387 aa

OverviewNCBI Gene

No narrative summary is available for FAM153B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>P0C7A2|FAM153B
     1  MGCAYSCCLE VCCGEDEIVY PRMPGESTVC HREREKPITY HWYHWHPGHI YPRVASMEDY
    61  DEDLVQEASS EDVLGVHMVD KDTERDIEMK RQLRRLRELH LYSTWKKYQE AMKTSLGVPQ
   121  CERDEGSLGK PLCPPEILSE TLPGSVKKRV CFPSEDHLEE FIAEHLPEAS NQSLLTVAHA
   181  DTGIQTNGDL EDLEEHGPGQ TVSEEATEVH MMEGDPDTLA ELLIRDVLQE LSSYNGEEED
   241  PEEVKTSLGV PQRGDLEDLE EHVPGQTVSE EATGVHMMQV DPATPAKSDL EDLEEHVPGQ
   301  TVSEEATGVH MMQVDPATLA KQLEDSTITG SHQQMSASPS SAPAEEATEK TKVEEEVKTR
   361  KPKKKTRKPS KKSRWNVLKC WDIFNIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM153B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.45

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM153B as an antibody target. Whether an autoantibody or antibody against FAM153B could matter depends on whether native FAM153B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM153B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM153B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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