FAM153A
Protein FAM153A
Also known as: F153A_HUMAN, NY-REN-7
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UHL3
- Gene
- FAM153A
- Ensembl
- ENSG00000170074
- Chromosome
- 5
- Canonical length
- 310 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for FAM153A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
310 residues, UniProt reviewed canonical sequence.
>Q9UHL3|FAM153A
1 MVDKDTERDI EMKRQLRRLR ELHLYSTWKK YQEAMKTSLG VPQCERDEGS LGKPLCPPEI
61 LSETLPGSVK KRVCFPSEDH LEEFIAEHLP EASNQSLLTV AHADAGTQTN GDLEDLEEHG
121 PGQTVSEEAT EVHTMEGDPD TLAEFLIRDV LQELSSYNGE EEDPEEVKTS LGVPQRGDLE
181 DLEEHVPGQT VSEEATGVHM MQVDPATLAK SDLEDLEEHV PEQTVSEEAT GVHMMQVDPA
241 TLAKQLEDST ITGSHQQMSA SPSSAPAEEA TEKTKVEEEV KTRKPKKKTR KPSKKSRWNV
301 LKCWDIFNIFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM153A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.66
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- testis: 27 nTPM
- ovary: 5.1 nTPM
- cerebral cortex: 4.2 nTPM
- fallopian tube: 4.2 nTPM
- lymph node: 3.6 nTPM
- spleen: 3.5 nTPM
Single-cell type
- sertoli cells: 139 nCPM
- early spermatids: 133 nCPM
- somatotrophs: 113 nCPM
- epicardial cells: 111 nCPM
- granulosa cells: 95 nCPM
- brain excitatory neurons: 91 nCPM
Immune cell
- naive CD4 T-cell: 2.5 nTPM
- plasmacytoid DC: 1.8 nTPM
- naive CD8 T-cell: 1.1 nTPM
- memory CD4 T-cell: 0.4 nTPM
- naive B-cell: 0.3 nTPM
- T-reg: 0.3 nTPM
Brain region
- cerebellum: 78 nTPM
- cerebral cortex: 76 nTPM
- hippocampal formation: 64 nTPM
- amygdala: 52 nTPM
- white matter: 48 nTPM
- basal ganglia: 38 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.16
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.5
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM153A as an antibody target. Whether an autoantibody or antibody against FAM153A could matter depends on whether native FAM153A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM153A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM153A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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