Seroatlas · Human Serome Atlas

FAM151B

Protein FAM151B

Also known as: F151B_HUMAN, UNQ9217

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXP7
Gene: FAM151B
Ensembl: ENSG00000152380
Chromosome: 5
Canonical length: 276 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be involved in photoreceptor cell development. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>Q6UXP7|FAM151B
     1  MAASAGGPGS WSENILEYFL RNSQITAEDG AEITWYHAAN HKAQTNEALK STAHMIEADV
    61  LLPSDGSEHS QPIMAHPPET NSDNTLQEWL TEVMKSNKGI KLDFKSLAVV EPSMMLLENV
   121  KRHLKRPVWI NADILPGPNG NSKVIDAKPF LDTVISFFPD VTFSLGWTTG WHPEKVNEGY
   181  SWTMVKEMEY ICNELSQPVT FPVRAALVRQ SCSQLLWLLK KSNRYSLTIW TGKNDNYSVE
   241  DLLYIRDHFD KKQVFYDILE PQNHEFKQAI GIKVNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM151B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 4.4 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 4.4 nTPM
placenta: 1.7 nTPM
fallopian tube: 1.2 nTPM
kidney: 1.1 nTPM
adrenal gland: 1 nTPM
cerebral cortex: 1 nTPM

Single-cell type

neutrophil progenitors: 179 nCPM
neutrophils: 89 nCPM
ependymal cells: 54 nCPM
syncytiotrophoblasts: 46 nCPM
cytotrophoblasts: 40 nCPM
adrenal cortex cells: 36 nCPM

Immune cell

myeloid DC: 1 nTPM
eosinophil: 0.5 nTPM
classical monocyte: 0.4 nTPM
intermediate monocyte: 0.3 nTPM
non-classical monocyte: 0.1 nTPM
total PBMC: 0.1 nTPM

Brain region

hippocampal formation: 3.3 nTPM
cerebral cortex: 3.1 nTPM
hypothalamus: 3.1 nTPM
basal ganglia: 2.7 nTPM
white matter: 2.7 nTPM
amygdala: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

photoreceptor cell development

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM151B as an antibody target. Whether an autoantibody or antibody against FAM151B could matter depends on whether native FAM151B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM151B is annotated as secreted, so native FAM151B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM151B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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