Seroatlas · Human Serome Atlas

FAM151A

Protein FAM151A

Also known as: C1orf179, F151A_HUMAN, MGC27169

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WW52
Gene: FAM151A
Ensembl: ENSG00000162391
Chromosome: 1
Canonical length: 585 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in extracellular exosome. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q8WW52|FAM151A
     1  MVCREQLSKN QVKWVFAGIT CVSVVVIAAI VLAITLRRPG CELEACSPDA DMLDYLLSLG
    61  QISRRDALEV TWYHAANSKK AMTAALNSNI TVLEADVNVE GLGTANETGV PIMAHPPTIY
   121  SDNTLEQWLD AVLGSSQKGI KLDFKNIKAV GPSLDLLRQL TEEGKVRRPI WINADILKGP
   181  NMLISTEVNA TQFLALVQEK YPKATLSPGW TTFYMSTSPN RTYTQAMVEK MHELVGGVPQ
   241  RVTFPVRSSM VRAAWPHFSW LLSQSERYSL TLWQAASDPM SVEDLLYVRD NTAVHQVYYD
   301  IFEPLLSQFK QLALNATRKP MYYTGGSLIP LLQLPGDDGL NVEWLVPDVQ GSGKTATMTL
   361  PDTEGMILLN TGLEGTVAEN PVPIVHTPSG NILTLESCLQ QLATHPGHWG IHLQIAEPAA
   421  LRPSLALLAR LSSLGLLHWP VWVGAKISHG SFSVPGHVAG RELLTAVAEV FPHVTVAPGW
   481  PEEVLGSGYR EQLLTDMLEL CQGLWQPVSF QMQAMLLGHS TAGAIGRLLA SSPRATVTVE
   541  HNPAGGDYAS VRTALLAARA VDRTRVYYRL PQGYHKDLLA HVGRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM151A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 163 nTPM

Expression across tissuesHPA

Tissue

kidney: 163 nTPM
small intestine: 68 nTPM
liver: 16 nTPM
lymph node: 5 nTPM
heart muscle: 2.8 nTPM
colon: 2.3 nTPM

Single-cell type

enterocytes: 470 nCPM
cardiomyocytes: 234 nCPM
myonuclei: 69 nCPM
retinal ganglion cells: 62 nCPM
proximal tubule cells: 60 nCPM
enteric transient amplifying cells: 26 nCPM

Immune cell

eosinophil: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 17 nTPM
midbrain: 12 nTPM
medulla oblongata: 11 nTPM
thalamus: 9.8 nTPM
cerebellum: 8.3 nTPM
pons: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM151A as an antibody target. Whether an autoantibody or antibody against FAM151A could matter depends on whether native FAM151A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM151A is annotated as secreted, so native FAM151A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM151A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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