Seroatlas · Human Serome Atlas

FAM149A

Protein FAM149A

Also known as: DKFZP564J102, F149A_HUMAN, MST119, MSTP119

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A5PLN7
Gene
FAM149A
Ensembl
ENSG00000109794
Chromosome
4
Canonical length
773 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for FAM149A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

773 residues, UniProt reviewed canonical sequence.

>A5PLN7|FAM149A
     1  MKAAVLDLGS LLAKLFETST APPAGPSSRP SGGAAAAGSG GSRAGTPLGT APTLLRALAP
    61  DSPSASRRSP APLLSSPYSR GSAASRAAGA VGTLLSWPSS PRAGKAPPQP PTPSGGGCSP
   121  ARLVVPARPP SGPGGVWAAL PRNPLQPGPG ERELGACVAP GAGPRTLFLT LPDIGEEGAS
   181  DGDSGDGEAR GLSEGRRRHG FTVRSKDSLP THFTRNVQKA IDKYTCKSLS SFSSSGSHTP
   241  TGAHTSWSGS ATQSSTTGSS TERGSVYSWR DDEFDEASSQ SVQRLLWEVE EMLFEGKVNP
   301  QTQSLLAECG EWTRRSLHLR VLGRQLILPT DKGVQHFQGS TPASAVHRPP LSACGHSSNI
   361  RELCISGSQI VPAALSASAL PGPDDTGVAD LTARSSLEEE VYHVDGKIEE YFAFDRKEDD
   421  DECLEQKPAQ PGRKWRKLGL PPVSPRDCVK DAVAAEVFDH VWTNMVELLE ELIRKHWETT
   481  LTEGKKQRET LKVAGNRFPH VLVPHAHADG ASGPPSGHAE AHGISLASRL NPPQIHHFSS
   541  SFYSDMNGVM TIQAKPLQRR PAYFADRTQN EKEDKASGGG AGALSSAPHR LGRASDTHGL
   601  SPSAKKTPVP WRLPSLASDS QRLKTPNIYS DEVLRGTKLP TGVDHMASPL VQTSRSRFPP
   661  LVTETRGQNT AVPGCRLVSY RGRHLQNRVL SAMPDGTERS RLRERTATLE RLSRPSTTHT
   721  FRQSDTPRKS SLTQMEFAAH TWTGQSILTG SQYVPKSFQR TTLTFKRRFQ VTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM149A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • liver: 47 nTPM
  • basal ganglia: 34 nTPM
  • kidney: 33 nTPM
  • amygdala: 27 nTPM
  • cerebral cortex: 26 nTPM
  • hippocampal formation: 24 nTPM

Single-cell type

  • microglia: 620 nCPM
  • cone photoreceptor cells: 182 nCPM
  • pancreatic duct cells: 168 nCPM
  • rod photoreceptor cells: 160 nCPM
  • choroid plexus epithelial cells: 150 nCPM
  • respiratory ciliated cells: 146 nCPM

Immune cell

  • T-reg: 1.2 nTPM
  • memory B-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • basophil: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM

Brain region

  • hippocampal formation: 31 nTPM
  • basal ganglia: 26 nTPM
  • choroid plexus: 25 nTPM
  • hypothalamus: 24 nTPM
  • cerebral cortex: 23 nTPM
  • amygdala: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
-0.32
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM149A as an antibody target. Whether an autoantibody or antibody against FAM149A could matter depends on whether native FAM149A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM149A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM149A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM149A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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