Seroatlas · Human Serome Atlas

FAM13C

Protein FAM13C

Also known as: FA13C_HUMAN, FAM13C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NE31
Gene: FAM13C
Ensembl: ENSG00000148541
Chromosome: 10
Canonical length: 585 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for FAM13C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q8NE31|FAM13C
     1  MFSCFCFSLQ DNSFSSTTVT ECDEDPVSLH EDQTDCSSLR DENNKENYPD AGALVEEHAP
    61  PSWEPQQQNV EATVLVDSVL RPSMGNFKSR KPKSIFKAES GRSHGESQET EHVVSSQSEC
   121  QVRAGTPAHE SPQNNAFKCQ ETVRLQPRID QRTAISPKDA FETRQDLNEE EAAQVHGVKD
   181  PAPASTQSVL ADGTDSADPS PVHKDGQNEA DSAPEDLHSV GTSRLLYHIT DGDNPLLSPR
   241  CSIFSQSQRF NLDPESAPSP PSTQQFMMPR SSSRCSCGDG KEPQTITQLT KHIQSLKRKI
   301  RKFEEKFEQE KKYRPSHGDK TSNPEVLKWM NDLAKGRKQL KELKLKLSEE QGSAPKGPPR
   361  NLLCEQPTVP RENGKPEAAG PEPSSSGEET PDAALTCLKE RREQLPPQED SKVTKQDKNL
   421  IKPLYDRYRI IKQILSTPSL IPTIQEEEDS DEDRPQGSQQ PSLADPASHL PVGDHLTYSN
   481  ETEPVRALLP DEKKEVKPPA LSMSNLHEAT MPVLLDHLRE TRADKKRLRK ALREFEEQFF
   541  KQTGRSPQKE DRIPMADEYY EYKHIKAKLR LLEVLISKQD VAKTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM13C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 38 nTPM
midbrain: 26 nTPM
cerebral cortex: 22 nTPM
tongue: 21 nTPM
hippocampal formation: 19 nTPM
amygdala: 17 nTPM

Single-cell type

oligodendrocytes: 572 nCPM
renal collecting duct intercalated cells: 269 nCPM
salivary ionocytes: 249 nCPM
prostatic glandular cells: 181 nCPM
pericytes: 158 nCPM
thymic myoid cells: 158 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 152 nTPM
medulla oblongata: 120 nTPM
basal ganglia: 110 nTPM
pons: 96 nTPM
thalamus: 94 nTPM
midbrain: 92 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0
gnomAD missense Z: 1.76
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM13C as an antibody target. Whether an autoantibody or antibody against FAM13C could matter depends on whether native FAM13C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM13C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM13C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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