Seroatlas · Human Serome Atlas

FAM135A

Protein FAM135A

Also known as: F135A_HUMAN, FLJ20176, KIAA1411

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2D6
Gene: FAM135A
Ensembl: ENSG00000082269
Chromosome: 6
Canonical length: 1515 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in lipid metabolic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1515 residues, UniProt reviewed canonical sequence.

>Q9P2D6|FAM135A
     1  MTEVQAMVEF SVELNKFYNV DLFQRGFYQI RASMKIPSRI PHRVEASLLH ATGMTLAFPA
    61  SVHDSLICSK TFQILYKNEE VVLNDVMIFK VKMLLDERKI EETLEEMNFL LSLDLHFTDG
   121  DYSADDLNAL QLISSRTLKL HFSPHRGLHH HVNVMFDYFH LSVVSVTVHA SLVALHQPLI
   181  SFPRPVKTTW LNRNAPAQNK DSVIPTLESV VFGINYTKQL SPDGCSFIIA DSFLHHAYRF
   241  HYTLCATLLL AFKGLHSYFI TVTEEIPSCQ KLELEEMDVE ARLTELCEEV KKIENPDELA
   301  ELINMNLAQL CSLLMALWGQ FLEVITLHEE LRILLAQEHH TLRVRRFSEA FFCFEHPREA
   361  AIAYQELHAQ SHLQMCTAIK NTSFCSSLPP LPIECSELDG DLNSLPIIFE DRYLDSVTED
   421  LDAPWMGIQN LQRSESSKMD KYETEESSVA GLSSPELKVR PAGASSIWYT EGEKQLTKSL
   481  KGKNEESNKS KVKVTKLMKT MKSENTKKLI KQNSKDSVVL VGYKCLKSTA SNDLIKCFEG
   541  NPSHSQKEGL DPTICGYNFD PKTYMRQTSQ KEASCLPTNT ERTEQKSPDI ENVQPDQFDP
   601  LNSGNLNLCA NLSISGKLDI SQDDSEITQM EHNLASRRSS DDCHDHQTTP SLGVRTIEIK
   661  PSNKDPFSGE NITVKLGPWT ELRQEEILVD NLLPNFESLE SNGKSKSIEI TFEKEALQEA
   721  KCLSIGESLT KLRSNLPAPS TKEYHVVVSG DTIKLPDISA TYASSRFSDS GVESEPSSFA
   781  THPNTDLVFE TVQGQGPCNS ERLFPQLLMK PDYNVKFSLG NHCTESTSAI SEIQSSLTSI
   841  NSLPSDDELS PDENSKKSVV PECHLNDSKT VLNLGTTDLP KCDDTKKSSI TLQQQSVVFS
   901  GNLDNETVAI HSLNSSIKDP LQFVFSDEET SSDVKSSCSS KPNLDTMCKG FQSPDKSNNS
   961  TGTAITLNSK LICLGTPCVI SGSISSNTDV SEDRTMKKNS DVLNLTQMYS EIPTVESETH
  1021  LGTSDPFSAS TDIVKQGLVE NYFGSQSSTD ISDTCAVSYS NALSPQKETS EKEISNLQQE
  1081  QDKEDEEEEQ DQQMVQNGYY EETDYSALDG TINAHYTSRD ELMEERLTKS EKINSDYLRD
  1141  GINMPTVCTS GCLSFPSAPR ESPCNVKYSS KSKFDAITKQ PSSTSYNFTS SISWYESSPK
  1201  PQIQAFLQAK EELKLLKLPG FMYSEVPLLA SSVPYFSVEE EDGSEDGVHL IVCVHGLDGN
  1261  SADLRLVKTY IELGLPGGRI DFLMSERNQN DTFADFDSMT DRLLDEIIQY IQIYSLTVSK
  1321  ISFIGHSLGN LIIRSVLTRP RFKYYLNKLH TFLSLSGPHL GTLYNSSALV NTGLWFMQKW
  1381  KKSGSLLQLT CRDHSDPRQT FLYKLSNKAG LHYFKNVVLV GSLQDRYVPY HSARIEMCKT
  1441  ALKDKQSGQI YSEMIHNLLR PVLQSKDCNL VRYNVINALP NTADSLIGRA AHIAVLDSEI
  1501  FLEKFFLVAA LKYFQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM135A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

esophagus: 28 nTPM
prostate: 15 nTPM
duodenum: 13 nTPM
small intestine: 11 nTPM
rectum: 10 nTPM
colon: 10 nTPM

Single-cell type

retinal horizontal cells: 1,274 nCPM
esophageal apical cells: 771 nCPM
prostatic glandular cells: 763 nCPM
esophageal suprabasal cells: 377 nCPM
microglia: 323 nCPM
pancreatic islet cells: 295 nCPM

Immune cell

myeloid DC: 3.5 nTPM
non-classical monocyte: 3.3 nTPM
NK-cell: 2.7 nTPM
classical monocyte: 2.2 nTPM
intermediate monocyte: 2 nTPM
naive B-cell: 2 nTPM

Brain region

cerebellum: 35 nTPM
cerebral cortex: 25 nTPM
white matter: 25 nTPM
basal ganglia: 24 nTPM
medulla oblongata: 23 nTPM
midbrain: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 1
gnomAD missense Z: 1.33
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid metabolic process

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM135A as an antibody target. Whether an autoantibody or antibody against FAM135A could matter depends on whether native FAM135A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM135A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM135A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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