FAM131C
Protein FAM131C
Also known as: C1orf117, F131C_HUMAN, FLJ36766
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96AQ9
- Gene
- FAM131C
- Ensembl
- ENSG00000185519
- Chromosome
- 1
- Canonical length
- 280 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Intermediate filaments,Cytosol
OverviewNCBI Gene
No narrative summary is available for FAM131C in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
280 residues, UniProt reviewed canonical sequence.
>Q96AQ9|FAM131C
1 MGSCVSRDLF TSAHKNCPMP QGADPLNPDL PSGRTPTVAP DCVIGKDKQM DFCWDPWQRC
61 FQTTNGYLSD SRSRPGNYNV AALATSSLVG VVQSIKDHIT KPTAMARGRV AHLIEWKGWS
121 AQPAGWELSP AEDEHYCCLP DELREARFAA GVAEQFAITE ATLSAWSSLD EEELHPENSP
181 QGIVQLQDLE SIYLQDSLPS GPSQDDSLQA FSSPSPSPDS CPSPEEPPST AGIPQPPSPE
241 LQHRRRLPGA QGPEGGTHPP GSLPSMDSGS LWEEDEVFYNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM131C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 72 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 72 nTPM
- spinal cord: 44 nTPM
- midbrain: 22 nTPM
- kidney: 19 nTPM
- cerebral cortex: 14 nTPM
- hypothalamus: 14 nTPM
Single-cell type
- respiratory ionocytes: 69 nCPM
- epididymal clear cells: 31 nCPM
- retinal horizontal cells: 18 nCPM
- loop of henle epithelial cells: 16 nCPM
- müller glia: 15 nCPM
- pancreatic islet cells: 15 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 82 nTPM
- white matter: 40 nTPM
- pons: 36 nTPM
- medulla oblongata: 32 nTPM
- hypothalamus: 29 nTPM
- midbrain: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.89
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.19
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM131C as an antibody target. Whether an autoantibody or antibody against FAM131C could matter depends on whether native FAM131C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM131C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM131C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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