FAM131B
Protein FAM131B
Also known as: F131B_HUMAN, KIAA0773
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86XD5
- Gene
- FAM131B
- Ensembl
- ENSG00000159784
- Chromosome
- 7
- Canonical length
- 332 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
332 residues, UniProt reviewed canonical sequence.
>Q86XD5|FAM131B
1 MDSTSSLHGS SLHRPSTEQT RTDFSWDGIN LSMEDTTSIL PKLKRNSNAY GIGALAKSSF
61 SGISRSMKDH VTKPTAMGQG RVAHMIEWQG WGKTPAVQPQ HSHESVRRDT DAYSDLSDGE
121 KEARFLAGVM EQFAISEATL MAWSSMDGED MSVNSTQEPL GCNYSDNYQE LMDSQDALAQ
181 APMDGWPHSY VSQGMYCLGS SDAWEASDQS LIASPATGSY LGPAFDDSQP SLHEMGPSQP
241 ASGYSALEPP PLLGGDTDWA PGVGAVDLAR GPAEEEKRPL APEEEEDAGC RDLESLSPRE
301 DPEMSTALSR KVSDVTSSGV QSFDEEEGEA NNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM131B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 55 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 55 nTPM
- cerebral cortex: 37 nTPM
- spinal cord: 30 nTPM
- midbrain: 15 nTPM
- hippocampal formation: 13 nTPM
- amygdala: 11 nTPM
Single-cell type
- oligodendrocytes: 31 nCPM
- brain excitatory neurons: 18 nCPM
- oligodendrocyte progenitor cells: 13 nCPM
- brain inhibitory neurons: 9.7 nCPM
- other brain neurons: 8.4 nCPM
- late spermatids: 6.9 nCPM
Immune cell
- gdT-cell: 0.3 nTPM
- MAIT T-cell: 0.1 nTPM
- naive CD8 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 85 nTPM
- white matter: 81 nTPM
- pons: 70 nTPM
- cerebellum: 62 nTPM
- medulla oblongata: 56 nTPM
- midbrain: 54 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.26
- gnomAD pLI
- 0.99
- gnomAD missense Z
- 1.42
- DepMap mean gene effect
- 0.15
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM131B as an antibody target. Whether an autoantibody or antibody against FAM131B could matter depends on whether native FAM131B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM131B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM131B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...