FAM131A
Protein FAM131A
Also known as: C3orf40, F131A_HUMAN, MGC21688
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UXB0
- Gene
- FAM131A
- Ensembl
- ENSG00000175182
- Chromosome
- 3
- Canonical length
- 366 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli rim,Mitotic chromosome
OverviewNCBI Gene
No narrative summary is available for FAM131A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
366 residues, UniProt reviewed canonical sequence.
>Q6UXB0|FAM131A
1 MPMISVLGKM FLWQREGPGG RWTCQTSRRV SSDPAWAVEW IELPRGLSLS SLGSARTLRG
61 WSRSSRPSSV DSQDLPEVNV GDTVAMLPKS RRALTIQEIA ALARSSLHGI SQVVKDHVTK
121 PTAMAQGRVA HLIEWKGWSK PSDSPAALES AFSSYSDLSE GEQEARFAAG VAEQFAIAEA
181 KLRAWSSVDG EDSTDDSYDE DFAGGMDTDM AGQLPLGPHL QDLFTGHRFS RPVRQGSVEP
241 ESDCSQTVSP DTLCSSLCSL EDGLLGSPAR LASQLLGDEL LLAKLPPSRE SAFRSLGPLE
301 AQDSLYNSPL TESCLSPAEE EPAPCKDCQP LCPPLTGSWE RQRQASDLAS SGVVSLDEDE
361 AEPEEQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM131A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 97 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 97 nTPM
- hippocampal formation: 79 nTPM
- cerebellum: 63 nTPM
- basal ganglia: 59 nTPM
- amygdala: 53 nTPM
- pituitary gland: 51 nTPM
Single-cell type
- lactotrophs: 86 nCPM
- adrenal medulla cells: 64 nCPM
- somatotrophs: 61 nCPM
- syncytiotrophoblasts: 55 nCPM
- gonadotrophs: 49 nCPM
- brain excitatory neurons: 43 nCPM
Immune cell
- neutrophil: 8.4 nTPM
- intermediate monocyte: 4.9 nTPM
- eosinophil: 4.8 nTPM
- myeloid DC: 4.2 nTPM
- classical monocyte: 3.8 nTPM
- non-classical monocyte: 2.7 nTPM
Brain region
- hippocampal formation: 135 nTPM
- cerebral cortex: 111 nTPM
- basal ganglia: 98 nTPM
- amygdala: 77 nTPM
- white matter: 76 nTPM
- hypothalamus: 74 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.69
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 1.64
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM131A as an antibody target. Whether an autoantibody or antibody against FAM131A could matter depends on whether native FAM131A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM131A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM131A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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