Seroatlas · Human Serome Atlas

FAM124A

Protein FAM124A

Also known as: F124A_HUMAN, FLJ30707

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86V42
Gene: FAM124A
Ensembl: ENSG00000150510
Chromosome: 13
Canonical length: 546 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for FAM124A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

546 residues, UniProt reviewed canonical sequence.

>Q86V42|FAM124A
     1  MDPKAGGGGE EDDCVDSGAE TGGSDYSHLS STSSELSVEE AQDPFLVSIH IIADPGESQP
    61  LQEAIDNVLA WIHPDLPLFR VSERRASRRR RKPPKGAQPA LAVVLFLQEE YGEEQILQLH
   121  RTLQQPPWRH HHTEQVHGRF LPYLPCSQDF FTLAPGTPLW AIRPVHYGKE IVRFTVYCRY
   181  DNYADSLRFY QLILRRSPSQ KKADFCIFPI FSNLDVDIQF SLKRLPCDQC PVPTDSSVLE
   241  FRVRDIGELV PLLPNPCSPI SEGRWQTEDH DGNKILLQAQ RVHKKFPKPG RVHHASEKKR
   301  HSTPLPSTAV PSHTPGSSQQ SPLNSPHPGP IRTGLPPGHQ QEFAGRANST PNPPWSFQRS
   361  KSLFCLPTGG PSLASSAEPQ WFSNTGAPGH RASEWRHGHL LSIDDLEGAQ ETDVDTGLRL
   421  SSSDLSVVSA YSAPSRFCST VETPLPSERC SSHWAAHKDS REGPLPTVSR VTTEASWASL
   481  PFFTKRSSSS SATARAAPPA PSTSTLTDSS PQLPCDTPKV KQTDGDMPPP PGSAGPGDND
   541  MEEFYI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM124A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 28 nTPM
retina: 24 nTPM
choroid plexus: 21 nTPM
midbrain: 15 nTPM
hippocampal formation: 13 nTPM
basal ganglia: 8.2 nTPM

Single-cell type

oligodendrocytes: 278 nCPM
choroid plexus epithelial cells: 171 nCPM
rod photoreceptor cells: 118 nCPM
ependymal cells: 101 nCPM
cone photoreceptor cells: 93 nCPM
epicardial cells: 61 nCPM

Immune cell

basophil: 0.6 nTPM
neutrophil: 0.3 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

white matter: 126 nTPM
medulla oblongata: 79 nTPM
basal ganglia: 73 nTPM
pons: 69 nTPM
midbrain: 65 nTPM
choroid plexus: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM124A as an antibody target. Whether an autoantibody or antibody against FAM124A could matter depends on whether native FAM124A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM124A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM124A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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