Seroatlas · Human Serome Atlas

FAM120B

Constitutive coactivator of peroxisome proliferator-activated receptor gamma

Also known as: CCPG, F120B_HUMAN, KIAA1838, PGCC1, SAN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EK7
Gene: FAM120B
Ensembl: ENSG00000112584
Chromosome: 6
Canonical length: 910 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in fat cell differentiation and peroxisome proliferator activated receptor signaling pathway. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

910 residues, UniProt reviewed canonical sequence.

>Q96EK7|FAM120B
     1  MGVRGLQGFV GSTCPHICTV VNFKELAEHH RSKYPGCTPT IVVDAMCCLR YWYTPESWIC
    61  GGQWREYFSA LRDFVKTFTA AGIKLIFFFD GMVEQDKRDE WVKRRLKNNR EISRIFHYIK
   121  SHKEQPGRNM FFIPSGLAVF TRFALKTLGQ ETLCSLQEAD YEVASYGLQH NCLGILGEDT
   181  DYLIYDTCPY FSISELCLES LDTVMLCREK LCESLGLCVA DLPLLACLLG NDIIPEGMFE
   241  SFRYKCLSSY TSVKENFDKK GNIILAVSDH ISKVLYLYQG EKKLEEILPL GPNKALFYKG
   301  MASYLLPGQK SPWFFQKPKG VITLDKQVIS TSSDAESREE VPMCSDAESR QEVPMCTGPE
   361  SRREVPVYTD SEPRQEVPMC SDPEPRQEVP TCTGPESRRE VPMCSDPEPR QEVPMCTGPE
   421  ARQEVPMYTD SEPRQEVPMY TDSEPRQEVP MYTGSEPRQE VPMYTGPESR QEVPMYTGPE
   481  SRQEVLIRTD PESRQEIMCT GHESKQEVPI CTDPISKQED SMCTHAEINQ KLPVATDFEF
   541  KLEALMCTNP EIKQEDPTNV GPEVKQQVTM VSDTEILKVA RTHHVQAESY LVYNIMSSGE
   601  IECSNTLEDE LDQALPSQAF IYRPIRQRVY SLLLEDCQDV TSTCLAVKEW FVYPGNPLRH
   661  PDLVRPLQMT IPGGTPSLKI LWLNQEPEIQ VRRLDTLLAC FNLSSSREEL QAVESPFQAL
   721  CCLLIYLFVQ VDTLCLEDLH AFIAQALCLQ GKSTSQLVNL QPDYINPRAV QLGSLLVRGL
   781  TTLVLVNSAC GFPWKTSDFM PWNVFDGKLF HQKYLQSEKG YAVEVLLEQN RSRLTKFHNL
   841  KAVVCKACMK ENRRITGRAH WGSHHAGRWG RQGSSYHRTG SGYSRSSQGQ PWRDQGPGSR
   901  QYEHDQWRRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM120B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 16 nTPM
testis: 14 nTPM
blood vessel: 13 nTPM
cerebellum: 13 nTPM
salivary gland: 13 nTPM
cerebral cortex: 13 nTPM

Single-cell type

late spermatids: 2,299 nCPM
early spermatids: 525 nCPM
renal collecting duct intercalated cells: 273 nCPM
choroid plexus epithelial cells: 238 nCPM
ependymal cells: 186 nCPM
distal convoluted tubule cells: 172 nCPM

Immune cell

basophil: 17 nTPM
NK-cell: 12 nTPM
non-classical monocyte: 10 nTPM
neutrophil: 10 nTPM
eosinophil: 7.5 nTPM
total PBMC: 6.7 nTPM

Brain region

cerebellum: 26 nTPM
cerebral cortex: 26 nTPM
pons: 25 nTPM
choroid plexus: 24 nTPM
white matter: 24 nTPM
midbrain: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM120B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM120B as an antibody target. Whether an autoantibody or antibody against FAM120B could matter depends on whether native FAM120B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM120B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM120B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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