FAM120AOS
Uncharacterized protein FAM120AOS
Also known as: C9orf10OS, F120S_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T036
- Gene
- FAM120AOS
- Ensembl
- ENSG00000188938
- Chromosome
- 9
- Canonical length
- 256 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Differences in the expression level of this gene are associated with the survival rate of those with glioma. [provided by RefSeq, May 2017]
Canonical amino-acid sequenceUniProt
256 residues, UniProt reviewed canonical sequence.
>Q5T036|FAM120AOS
1 MGKTKDIGDD DTVASEFWSG ALSQPSSVPT RPRTPNRDSW RRAWAARGLH PRPSILQPGP
61 ARLSRARAGG TRCPQRRHGR ATFCALGRGI GVRRGPGPRP ARIPGLTLTW KRMSARRMQW
121 AMQTGGRNQT FGGGVPLFWT WLTICCAVWR SLPCRLTHSC SRAFSSAPLK KTKSSMLPPK
181 QALASAARNL CRGAGCNRQA VAGQLLPSTW SLHAHGLAKE APILPVKKIS RSCSVNNKVS
241 KKTTKPPTLR SFLSPILocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM120AOS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 34 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 34 nTPM
- pituitary gland: 33 nTPM
- thyroid gland: 27 nTPM
- parathyroid gland: 26 nTPM
- blood vessel: 26 nTPM
- colon: 25 nTPM
Single-cell type
- syncytiotrophoblasts: 425 nCPM
- extravillous trophoblasts: 261 nCPM
- migrating cytotrophoblasts: 217 nCPM
- cytotrophoblasts: 158 nCPM
- colonocytes: 136 nCPM
- esophageal apical cells: 125 nCPM
Immune cell
- basophil: 13 nTPM
- memory B-cell: 12 nTPM
- non-classical monocyte: 11 nTPM
- neutrophil: 11 nTPM
- classical monocyte: 9 nTPM
- intermediate monocyte: 8.9 nTPM
Brain region
- white matter: 21 nTPM
- medulla oblongata: 21 nTPM
- thalamus: 20 nTPM
- cerebral cortex: 19 nTPM
- amygdala: 19 nTPM
- hypothalamus: 19 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about FAM120AOS.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 48 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.99
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.74
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM120AOS as an antibody target. Whether an autoantibody or antibody against FAM120AOS could matter depends on whether native FAM120AOS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM120AOS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM120AOS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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