Seroatlas · Human Serome Atlas

FAM118A

Protein FAM118A

Also known as: bK268H5.C22.4, C22orf8, F118A_HUMAN, FLJ20635

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWS6
Gene: FAM118A
Ensembl: ENSG00000100376
Chromosome: 22
Canonical length: 357 aa
Protein class: Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q9NWS6|FAM118A
     1  MDSVEKTTNR SEQKSRKFLK SLIRKQPQEL LLVIGTGVSA AVAPGIPALC SWRSCIEAVI
    61  EAAEQLEVLH PGDVAEFRRK VTKDRDLLVV AHDLIRKMSP RTGDAKPSFF QDCLMEVFDD
   121  LEQHIRSPVV LQSILSLMDR GAMVLTTNYD NLLEAFGRRQ NKPMESLDLK DKTKVLEWAR
   181  GHMKYGVLHI HGLYTDPCGV VLDPSGYKDV TQDAEVMEVL QNLYRTKSFL FVGCGETLRD
   241  QIFQALFLYS VPNKVDLEHY MLVLKENEDH FFKHQADMLL HGIKVVSYGD CFDHFPGYVQ
   301  DLATQICKQQ SPDADRVDST TLLGNACQDC AKRKLEENGI EVSKKRTQSD TDDAGGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM118A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

epididymis: 63 nTPM
prostate: 47 nTPM
lymph node: 46 nTPM
pituitary gland: 43 nTPM
skin: 38 nTPM
parathyroid gland: 36 nTPM

Single-cell type

microglia: 171 nCPM
early spermatids: 167 nCPM
ependymal cells: 165 nCPM
syncytiotrophoblasts: 147 nCPM
cytotrophoblasts: 138 nCPM
choroid plexus epithelial cells: 124 nCPM

Immune cell

plasmacytoid DC: 14 nTPM
naive CD4 T-cell: 12 nTPM
T-reg: 11 nTPM
myeloid DC: 8.7 nTPM
naive CD8 T-cell: 8.6 nTPM
memory CD4 T-cell: 7.3 nTPM

Brain region

choroid plexus: 62 nTPM
cerebellum: 54 nTPM
hypothalamus: 46 nTPM
hippocampal formation: 44 nTPM
basal ganglia: 43 nTPM
midbrain: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM118A as an antibody target. Whether an autoantibody or antibody against FAM118A could matter depends on whether native FAM118A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM118A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM118A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...