Seroatlas · Human Serome Atlas

FAM110D

Protein FAM110D

Also known as: F110D_HUMAN, FLJ14050, GRRP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAY7
Gene: FAM110D
Ensembl: ENSG00000197245
Chromosome: 1
Canonical length: 271 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM110D in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q8TAY7|FAM110D
     1  MLLAPPSTPS RGRTPSAVER LEADKAKYVK THQVIARRQE PALRGSPGPL TPHPCNELGP
    61  PASPRTPRPV RRGSGRRLPR PDSLIFYRQK RDCKASVNKE NAKGQGLVRR LFLGAPRDAA
   121  PSSPASTERP AASGGWAAPQ DAPEAAGKRA LCPTCSLPLS EKERFFNYCG LERALVEVLG
   181  AERFSPQSWG ADASPQAGTS PPPGSGDASD WTSSDRGVDS PGGAGGGGGS EAAGSARDRR
   241  PPVSVVERNA RVIQWLYGCQ RARGPPRESE V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM110D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 10 nTPM
breast: 8.2 nTPM
endometrium: 6.6 nTPM
fallopian tube: 6 nTPM
heart muscle: 6 nTPM
blood vessel: 4.6 nTPM

Single-cell type

vascular endothelial cells: 107 nCPM
hepatic stellate cells: 13 nCPM
respiratory ionocytes: 10 nCPM
lymphatic endothelial cells: 8.8 nCPM
cardiomyocytes: 5.8 nCPM
retinal pigment epithelial cells: 4.3 nCPM

Immune cell

basophil: 1.2 nTPM
neutrophil: 0.9 nTPM
naive B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM

Brain region

medulla oblongata: 8.8 nTPM
spinal cord: 8.7 nTPM
thalamus: 8.2 nTPM
pons: 8 nTPM
amygdala: 7.3 nTPM
cerebral cortex: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.39
gnomAD missense Z: 1.14
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM110D as an antibody target. Whether an autoantibody or antibody against FAM110D could matter depends on whether native FAM110D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM110D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM110D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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