Seroatlas · Human Serome Atlas

FAM110B

Protein FAM110B

Also known as: C8orf72, F110B_HUMAN, MGC39325

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TC76
Gene: FAM110B
Ensembl: ENSG00000169122
Chromosome: 8
Canonical length: 370 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q8TC76|FAM110B
     1  MPTETLQTGS MVKPVSPAGT FTSAVPLRIL NKGPDYFRRQ AEPNPKRLSA VERLEADKAK
    61  YVKSQEVINA KQEPVKPAVL AKPPVCPAAK RALGSPTLKV FGNHAKTESG VQRENLKLEI
   121  LKNIINSSEG SSSGSGHKHS SRNWPPHRSE ATDLHRHSFA ESLKVYPTQG RRSPQEGGSH
   181  VGRRLLEQSA ESFLHVSHSS SDIRKVTSVK PLKAIPCSSS APPLPPKPKI AAIASMKSPE
   241  ADPVEPACGV SRRPSLQRSK SDLSDRYFRV DADVERFFNY CGLDPEELEN LGMENFARAN
   301  SDIISLNFRS ASMISSDCEQ SQDSNSDLRN DDSANDRVPY GISAIERNAR IIKWLYSIKQ
   361  ARESQKVSHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM110B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

spleen: 21 nTPM
heart muscle: 14 nTPM
skeletal muscle: 12 nTPM
parathyroid gland: 11 nTPM
cerebral cortex: 11 nTPM
choroid plexus: 8 nTPM

Single-cell type

oligodendrocyte progenitor cells: 419 nCPM
sertoli cells: 393 nCPM
renal connecting tubule cells: 374 nCPM
choroid plexus epithelial cells: 316 nCPM
epididymal basal cells: 243 nCPM
myosatellite cells: 238 nCPM

Immune cell

eosinophil: 14 nTPM
non-classical monocyte: 7.1 nTPM
intermediate monocyte: 3.7 nTPM
classical monocyte: 1.5 nTPM
myeloid DC: 0.9 nTPM
total PBMC: 0.7 nTPM

Brain region

cerebellum: 41 nTPM
hypothalamus: 40 nTPM
cerebral cortex: 33 nTPM
pons: 32 nTPM
amygdala: 31 nTPM
thalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.36
gnomAD missense Z: 1.47
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM110B as an antibody target. Whether an autoantibody or antibody against FAM110B could matter depends on whether native FAM110B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM110B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM110B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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