Seroatlas · Human Serome Atlas

FAM107B

Protein FAM107B

Also known as: C10orf45, F107B_HUMAN, FLJ45505, HITS, MGC11034

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H098
Gene
FAM107B
Ensembl
ENSG00000065809
Chromosome
10
Canonical length
131 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to act upstream of or within sensory perception of sound. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>Q9H098|FAM107B
     1  MAEPDYIEDD NPELIRPQKL INPVKTSRNH QDLHRELLMN QKRGLAPQNK PELQKVMEKR
    61  KRDQVIKQKE EEAQKKKSDL EIELLKRQQK LEQLELEKQK LQEEQENAPE FVKVKGNLRR
   121  TGQEVAQAQE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM107B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
162 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 162 nTPM
  • lymph node: 142 nTPM
  • liver: 138 nTPM
  • spinal cord: 134 nTPM
  • tonsil: 126 nTPM
  • stomach: 116 nTPM

Single-cell type

  • neutrophils: 2,431 nCPM
  • neutrophil progenitors: 1,631 nCPM
  • urothelial cells: 1,282 nCPM
  • pancreatic acinar cells: 1,020 nCPM
  • monocytes: 948 nCPM
  • mast cells: 922 nCPM

Immune cell

  • naive CD8 T-cell: 107 nTPM
  • naive CD4 T-cell: 106 nTPM
  • gdT-cell: 101 nTPM
  • MAIT T-cell: 98 nTPM
  • memory CD8 T-cell: 85 nTPM
  • memory CD4 T-cell: 80 nTPM

Brain region

  • white matter: 394 nTPM
  • basal ganglia: 252 nTPM
  • medulla oblongata: 231 nTPM
  • midbrain: 205 nTPM
  • pons: 193 nTPM
  • thalamus: 188 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0
gnomAD missense Z
-0.55
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM107B as an antibody target. Whether an autoantibody or antibody against FAM107B could matter depends on whether native FAM107B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM107B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM107B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM107B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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