Seroatlas · Human Serome Atlas

FAIM

Fas apoptotic inhibitory molecule 1

Also known as: FAIM1, FAIM1_HUMAN, FLJ10582

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVQ4
Gene: FAIM
Ensembl: ENSG00000158234
Chromosome: 3
Canonical length: 179 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>Q9NVQ4|FAIM
     1  MTDLVAVWDV ALSDGVHKIE FEHGTTSGKR VVYVDGKEEI RKEWMFKLVG KETFYVGAAK
    61  TKATINIDAI SGFAYEYTLE INGKSLKKYM EDRSKTTNTW VLHMDGENFR IVLEKDAMDV
   121  WCNGKKLETA GEFVDDGTET HFSIGNHDCY IKAVSSGKRK EGIIHTLIVD NREIPEIAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAIM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 218 nTPM

Expression across tissuesHPA

Tissue

retina: 218 nTPM
fallopian tube: 36 nTPM
pancreas: 36 nTPM
cervix: 30 nTPM
spinal cord: 28 nTPM
seminal vesicle: 21 nTPM

Single-cell type

fallopian tube ciliated cells: 342 nCPM
endometrial ciliated cells: 191 nCPM
rod photoreceptor cells: 183 nCPM
respiratory ciliated cells: 139 nCPM
epididymal efferent duct ciliated cells: 97 nCPM
cone photoreceptor cells: 81 nCPM

Immune cell

NK-cell: 19 nTPM
basophil: 17 nTPM
memory B-cell: 17 nTPM
naive B-cell: 12 nTPM
gdT-cell: 11 nTPM
naive CD8 T-cell: 9.8 nTPM

Brain region

white matter: 16 nTPM
medulla oblongata: 15 nTPM
spinal cord: 15 nTPM
hypothalamus: 14 nTPM
pons: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Fas apoptotic inhibitory molecule 1
FAIM1 domain superfamily
Fas apoptotic inhibitory molecule (FAIM1)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAIM as an antibody target. Whether an autoantibody or antibody against FAIM could matter depends on whether native FAIM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAIM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAIM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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