Seroatlas · Human Serome Atlas

FAHD2B

Oxaloacetate tautomerase FAHD2B, mitochondrial

Also known as: DKFZp434N062, FAH2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P2I3
Gene: FAHD2B
Ensembl: ENSG00000144199
Chromosome: 2
Canonical length: 314 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables oxaloacetate tautomerase activity. Involved in oxaloacetate metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q6P2I3|FAHD2B
     1  MLVSGRRRLL TALLQAQKWP FQPSRDMRLV QFRAPHLVGP HLGLETGNGG GVINLNAFDP
    61  TLPKTMTQFL EQGEATLSVA RRALAAQLPV LPWSEVTFLA PVTWPDKVVC VGMNYVDHCK
   121  EQNVPVPKEP IIFSKFASSI VGPYDEVVLP PQSQEVDWEV ELAVVIGKKG KHIKATDAMA
   181  HVAGFTVAHD VSARDWLTRR NGKQWLLGKT FDTFCPLGPA LVTKDSVADP HNLKICCRVN
   241  GEVVQSSNTN QMVFKTEDLI AWVSQFVTFY PGDVILTGTP PGVGVFRKPP VFLKKGDEVQ
   301  CEIEELGVII NKVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAHD2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

testis: 44 nTPM
tongue: 43 nTPM
epididymis: 36 nTPM
midbrain: 30 nTPM
basal ganglia: 30 nTPM
spinal cord: 30 nTPM

Single-cell type

late spermatids: 303 nCPM
early spermatids: 259 nCPM
late primary spermatocytes: 120 nCPM
epididymal principal cells: 118 nCPM
oocytes: 97 nCPM
parietal cells: 35 nCPM

Immune cell

NK-cell: 17 nTPM
MAIT T-cell: 16 nTPM
T-reg: 16 nTPM
gdT-cell: 12 nTPM
memory CD4 T-cell: 11 nTPM
memory CD8 T-cell: 11 nTPM

Brain region

white matter: 40 nTPM
spinal cord: 32 nTPM
cerebellum: 32 nTPM
thalamus: 31 nTPM
hypothalamus: 31 nTPM
medulla oblongata: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

oxaloacetate metabolic process

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAHD2B as an antibody target. Whether an autoantibody or antibody against FAHD2B could matter depends on whether native FAHD2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAHD2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAHD2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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