Seroatlas · Human Serome Atlas

FAHD2A

Oxaloacetate tautomerase FAHD2A, mitochondrial

Also known as: CGI-105, FAH2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GK7
Gene: FAHD2A
Ensembl: ENSG00000115042
Chromosome: 2
Canonical length: 314 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables oxaloacetate tautomerase activity. Involved in oxaloacetate metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q96GK7|FAHD2A
     1  MLVSGRRRLL TVLLQAQKWP FQPSRDMRLV QFRAPHLVGP HLGLETGNGG GVINLNAFDP
    61  TLPKTMTQFL EQGEATLSVA RRALAAQLPV LPRSEVTFLA PVTRPDKVVC VGMNYVDHCK
   121  EQNVPVPKEP IIFSKFASSI VGPYDEVVLP PQSQEVDWEV ELAVVIGKKG KHIKATDAMA
   181  HVAGFTVAHD VSARDWQMRR NGKQWLLGKT FDTFCPLGPA LVTKDSVADP HNLKICCRVN
   241  GEVVQSGNTN QMVFKTEDLI AWVSQFVTFY PGDVILTGTP PGVGVFRKPP VFLKKGDEVQ
   301  CEIEELGVII NKVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAHD2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 108 nTPM

Expression across tissuesHPA

Tissue

liver: 108 nTPM
salivary gland: 81 nTPM
tongue: 54 nTPM
heart muscle: 37 nTPM
skeletal muscle: 36 nTPM
thyroid gland: 35 nTPM

Single-cell type

lacrimal acinar cells: 76 nCPM
enterocytes: 65 nCPM
early spermatids: 60 nCPM
late spermatids: 53 nCPM
salivary acinar cells: 43 nCPM
parietal cells: 34 nCPM

Immune cell

plasmacytoid DC: 27 nTPM
myeloid DC: 23 nTPM
MAIT T-cell: 21 nTPM
T-reg: 20 nTPM
gdT-cell: 18 nTPM
intermediate monocyte: 18 nTPM

Brain region

white matter: 38 nTPM
cerebellum: 33 nTPM
cerebral cortex: 32 nTPM
basal ganglia: 31 nTPM
thalamus: 29 nTPM
pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

oxaloacetate metabolic process

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAHD2A as an antibody target. Whether an autoantibody or antibody against FAHD2A could matter depends on whether native FAHD2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAHD2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAHD2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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