FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial
Also known as: C16orf36, DKFZP566J2046, FAHD1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P587
- Gene
- FAHD1
- Ensembl
- ENSG00000180185
- Chromosome
- 16
- Canonical length
- 221 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Mitochondria
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; oxaloacetate decarboxylase activity; and oxaloacetate tautomerase activity. Involved in oxaloacetate metabolic process. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
221 residues, UniProt reviewed canonical sequence.
>Q6P587|FAHD1
1 MAASRPLSRF WEWGKNIVCV GRNYADHVRE MRSAVLSEPV LFLKPSTAYA PEGSPILMPA
61 YTRNLHHELE LGVVMGKRCR AVPEAAAMDY VGGYALCLDM TARDVQDECK KKGLPWTLAK
121 SFTASCPVSA FVPKEKIPDP HKLKLWLKVN GELRQEGETS SMIFSIPYII SYVSKIITLE
181 EGDIILTGTP KGVGPVKEND EIEAGIHGLV SMTFKVEKPE YLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAHD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 69 nTPM
Expression across tissuesHPA
Tissue
- kidney: 69 nTPM
- liver: 60 nTPM
- duodenum: 38 nTPM
- small intestine: 29 nTPM
- skeletal muscle: 28 nTPM
- tongue: 26 nTPM
Single-cell type
- early spermatids: 117 nCPM
- enterocytes: 99 nCPM
- esophageal suprabasal cells: 86 nCPM
- late spermatids: 69 nCPM
- esophageal apical cells: 65 nCPM
- esophageal basal cells: 60 nCPM
Immune cell
- intermediate monocyte: 35 nTPM
- non-classical monocyte: 29 nTPM
- myeloid DC: 28 nTPM
- classical monocyte: 28 nTPM
- NK-cell: 25 nTPM
- memory B-cell: 24 nTPM
Brain region
- cerebral cortex: 23 nTPM
- hypothalamus: 22 nTPM
- hippocampal formation: 22 nTPM
- midbrain: 21 nTPM
- pons: 21 nTPM
- white matter: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.97
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.84
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- metal ion binding
- oxaloacetate decarboxylase activity
- oxaloacetate tautomerase activity
- acetylpyruvate hydrolase activity
- acylpyruvate hydrolase activity
- fumarylpyruvate hydrolase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAHD1 as an antibody target. Whether an autoantibody or antibody against FAHD1 could matter depends on whether native FAHD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAHD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAHD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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