Seroatlas · Human Serome Atlas

FADS6

Fatty acid desaturase 6

Also known as: FADS6_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9I5
Gene: FADS6
Canonical length: 356 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for FADS6 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q8N9I5|FADS6
     1  MEPTEPMEPT EPMEPTEPME PARSAHRGGE ALLRELEVLV QDVVRTSSWW ERHGVDCAIL
    61  ALSLFALPAG FLCLRWENAL VFASGITILG VCHYTLTVKG SHLATHGALT ESKRWSKIWL
   121  LFFVEVCTAF TAEHATHGHV KMHHAYTNVV GLGDSSTWRL PCLNRYVYMF LAPFLLPIAT
   181  PLVAVERLRK VELGTALRTL ALISLGLYSH YWLLLNVSGF KNPSSALGCM FLTRSLLAHP
   241  YLHVNIFQHI GLPMFSRDNK PRRIHMMSLG VLNLARLPVL DWAFGHSIIS CHVEHHLFPR
   301  LSDNMCLKVK PVVSQFLREK QLPYNEDSYL ARFQLFLRRY EEFMVQAPPI TELVGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FADS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

epididymis: 17 nTPM
small intestine: 13 nTPM
cerebellum: 12 nTPM
duodenum: 7 nTPM
skin: 6.8 nTPM
adrenal gland: 6.5 nTPM

Single-cell type

enterocytes: 91 nCPM
epididymal principal cells: 36 nCPM
adrenal cortex cells: 18 nCPM
retinal amacrine cells: 8.4 nCPM
esophageal suprabasal cells: 7.9 nCPM
brain excitatory neurons: 7.4 nCPM

Immune cell

neutrophil: 1.7 nTPM
non-classical monocyte: 1.3 nTPM
basophil: 1.1 nTPM
NK-cell: 0.7 nTPM
intermediate monocyte: 0.6 nTPM
classical monocyte: 0.5 nTPM

Brain region

pons: 40 nTPM
cerebral cortex: 37 nTPM
cerebellum: 31 nTPM
medulla oblongata: 30 nTPM
thalamus: 29 nTPM
basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
oxidoreductase activity
acting on paired donors

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FADS6 as an antibody target. Whether an autoantibody or antibody against FADS6 could matter depends on whether native FADS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FADS6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FADS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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