Seroatlas · Human Serome Atlas

FADS2B

Putative fatty acid desaturase 2-like protein FADS2B

Also known as: FS2P1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MWK0
Gene: FADS2B
Canonical length: 482 aa

OverviewNCBI Gene

No narrative summary is available for FADS2B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>A8MWK0|FADS2B
     1  MKFEEKCGDN GSIVGRNQSY PGEKHQPKGK PIANGEAEVY AKQEANGKCS TPRKSLSMYT
    61  WLEIQRHNHE ADQLVINCKV YNVSSWADRH PGGHQVLNHC AGEDAMDVFR AMHPELDIVQ
   121  LYLKPLLIGE LAPGEPSQER HKNSQLVKDF QELWSIAEAM NMFHANLGFF FLHFVQILIL
   181  EVLAWLIVYH FGSGWPVTMF ISFLLTISQA SSSFLQHDAG HLSIFRKSKW NHVVHKFVMC
   241  HLKGLSADRW NYWHFEQHVK PNIYPKDPDI DTDPLFLLGD SQPVKYGKKK IKYINYEEQH
   301  LYFYKVWLPL FMPVYLKLPS MQAMYLQRYW VCFSLQDITW VSSFYIYFIT FGLYYGIFGT
   361  MLLIYLVKFL ESPWIVYVTQ MSHITMRMST EENRDWLTTQ VLATCNTESF FNDFTGHLNF
   421  QIEHHLFPTM PRHNYHKVAP LVRSLCAKHG LHYVNKPMLR AFGDIVRALK KSAALWADAY
   481  YE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FADS2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.29

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FADS2B as an antibody target. Whether an autoantibody or antibody against FADS2B could matter depends on whether native FADS2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FADS2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FADS2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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