Seroatlas · Human Serome Atlas

FADS1

Acyl-CoA (8-3)-desaturase

Also known as: D5D, FADS1_HUMAN, FADS6, FADSD5, LLCDL1, TU12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60427
Gene
FADS1
Ensembl
ENSG00000149485
Chromosome
11
Canonical length
444 aa
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>O60427|FADS1
     1  MAPDPVAAET AAQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYNISEFTR RHPGGSRVIS
    61  HYAGQDATDP FVAFHINKGL VKKYMNSLLI GELSPEQPSF EPTKNKELTD EFRELRATVE
   121  RMGLMKANHV FFLLYLLHIL LLDGAAWLTL WVFGTSFLPF LLCAVLLSAV QAQAGWLQHD
   181  FGHLSVFSTS KWNHLLHHFV IGHLKGAPAS WWNHMHFQHH AKPNCFRKDP DINMHPFFFA
   241  LGKILSVELG KQKKKYMPYN HQHKYFFLIG PPALLPLYFQ WYIFYFVIQR KKWVDLAWMI
   301  TFYVRFFLTY VPLLGLKAFL GLFFIVRFLE SNWFVWVTQM NHIPMHIDHD RNMDWVSTQL
   361  QATCNVHKSA FNDWFSGHLN FQIEHHLFPT MPRHNYHKVA PLVQSLCAKH GIEYQSKPLL
   421  SAFADIIHSL KESGQLWLDA YLHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FADS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
77 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 77 nTPM
  • adrenal gland: 64 nTPM
  • liver: 49 nTPM
  • cerebral cortex: 49 nTPM
  • amygdala: 47 nTPM
  • hippocampal formation: 40 nTPM

Single-cell type

  • thymic myoid cells: 288 nCPM
  • alveolar cells type 2: 199 nCPM
  • retinal pigment epithelial cells: 188 nCPM
  • adrenal cortex cells: 165 nCPM
  • megakaryocyte progenitors: 123 nCPM
  • schwann cells: 96 nCPM

Immune cell

  • intermediate monocyte: 41 nTPM
  • classical monocyte: 33 nTPM
  • myeloid DC: 28 nTPM
  • plasmacytoid DC: 24 nTPM
  • non-classical monocyte: 18 nTPM
  • total PBMC: 16 nTPM

Brain region

  • choroid plexus: 157 nTPM
  • thalamus: 156 nTPM
  • midbrain: 141 nTPM
  • hypothalamus: 134 nTPM
  • medulla oblongata: 132 nTPM
  • white matter: 125 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.37
gnomAD missense Z
3.67
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FADS1 as an antibody target. Whether an autoantibody or antibody against FADS1 could matter depends on whether native FADS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FADS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FADS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FADS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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