Seroatlas · Human Serome Atlas

FAAP24

Fanconi anemia core complex-associated protein 24

Also known as: C19orf40, FAP24_HUMAN, FLJ46828, MGC32020

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTP7
Gene: FAAP24
Ensembl: ENSG00000131944
Chromosome: 19
Canonical length: 215 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>Q9BTP7|FAAP24
     1  MEKNPPDDTG PVHVPLGHIV ANEKWRGSQL AQEMQGKIKL IFEDGLTPDF YLSNRCCILY
    61  VTEADLVAGN GYRKRLVRVR NSNNLKGIVV VEKTRMSEQY FPALQKFTVL DLGMVLLPVA
   121  SQMEASCLVI QLVQEQTKEP SKNPLLGKKR ALLLSEPSLL RTVQQIPGVG KVKAPLLLQK
   181  FPSIQQLSNA SIGELEQVVG QAVAQQIHAF FTQPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAAP24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

prostate: 5.4 nTPM
testis: 5.3 nTPM
tonsil: 3.1 nTPM
skin: 2.5 nTPM
bone marrow: 2.4 nTPM
lymph node: 2.4 nTPM

Single-cell type

late primary spermatocytes: 42 nCPM
extravillous trophoblasts: 20 nCPM
late spermatids: 18 nCPM
cytotrophoblasts: 15 nCPM
oocytes: 14 nCPM
migrating cytotrophoblasts: 13 nCPM

Immune cell

basophil: 12 nTPM
neutrophil: 12 nTPM
eosinophil: 7.9 nTPM
non-classical monocyte: 6.6 nTPM
plasmacytoid DC: 6.5 nTPM
intermediate monocyte: 6.3 nTPM

Brain region

white matter: 8.9 nTPM
medulla oblongata: 7.5 nTPM
cerebral cortex: 7.2 nTPM
choroid plexus: 6.9 nTPM
cerebellum: 6.8 nTPM
pons: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

interstrand cross-link repair

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RuvA domain 2-like
Fanconi anemia-associated protein of 24kDa
Fanconi anemia core complex-associated protein 24, pseudonuclease domain
DisA/LigA, helix-hairpin-helix motif
Helix-hairpin-helix motif
FANCM pseudonuclease domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAAP24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FANCM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAAP24 as an antibody target. Whether an autoantibody or antibody against FAAP24 could matter depends on whether native FAAP24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAAP24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAAP24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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