Seroatlas · Human Serome Atlas

FAAH2

Fatty-acid amide hydrolase 2

Also known as: AMDD, FAAH-2, FAAH2_HUMAN, FLJ31204, RP11-479E16.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6GMR7
Gene: FAAH2
Ensembl: ENSG00000165591
Chromosome: X
Canonical length: 532 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

532 residues, UniProt reviewed canonical sequence.

>Q6GMR7|FAAH2
     1  MAPSFTARIQ LFLLRALGFL IGLVGRAALV LGGPKFASKT PRPVTEPLLL LSGMQLAKLI
    61  RQRKVKCIDV VQAYINRIKD VNPMINGIVK YRFEEAMKEA HAVDQKLAEK QEDEATLENK
   121  WPFLGVPLTV KEAFQLQGMP NSSGLMNRRD AIAKTDATVV ALLKGAGAIP LGITNCSELC
   181  MWYESSNKIY GRSNNPYDLQ HIVGGSSGGE GCTLAAACSV IGVGSDIGGS IRMPAFFNGI
   241  FGHKPSPGVV PNKGQFPLAV GAQELFLCTG PMCRYAEDLA PMLKVMAGPG IKRLKLDTKV
   301  HLKDLKFYWM EHDGGSFLMS KVDQDLIMTQ KKVVVHLETI LGASVQHVKL KKMKYSFQLW
   361  IAMMSAKGHD GKEPVKFVDL LGDHGKHVSP LWELIKWCLG LSVYTIPSIG LALLEEKLRY
   421  SNEKYQKFKA VEESLRKELV DMLGDDGVFL YPSHPTVAPK HHVPLTRPFN FAYTGVFSAL
   481  GLPVTQCPLG LNAKGLPLGI QVVAGPFNDH LTLAVAQYLE KTFGGWVCPG KF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAAH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

pancreas: 14 nTPM
parathyroid gland: 13 nTPM
liver: 9.8 nTPM
skin: 9.2 nTPM
prostate: 6.9 nTPM
thymus: 6.8 nTPM

Single-cell type

pancreatic acinar cells: 458 nCPM
somatotrophs: 413 nCPM
thyrotrophs: 364 nCPM
lactotrophs: 363 nCPM
plasma cells: 303 nCPM
prostatic glandular cells: 294 nCPM

Immune cell

T-reg: 17 nTPM
memory CD4 T-cell: 8 nTPM
naive CD4 T-cell: 7.8 nTPM
MAIT T-cell: 5 nTPM
memory CD8 T-cell: 3.4 nTPM
memory B-cell: 1.8 nTPM

Brain region

cerebellum: 8.1 nTPM
hypothalamus: 6.8 nTPM
midbrain: 4 nTPM
medulla oblongata: 3.7 nTPM
pons: 3.7 nTPM
basal ganglia: 3.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FAAH2.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 222 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Meckel-like syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -3.63
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

fatty acid amide hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAAH2 as an antibody target. Whether an autoantibody or antibody against FAAH2 could matter depends on whether native FAAH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAAH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAAH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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